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The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology.
Obergasteiger J, Castonguay AM, Pizzi S, Magnabosco S, Frapporti G, Lobbestael E, Baekelandt V, Hicks AA, Pramstaller PP, Gravel C, Corti C, Lévesque M, Volta M. Obergasteiger J, et al. Among authors: castonguay am. NPJ Parkinsons Dis. 2023 Mar 27;9(1):44. doi: 10.1038/s41531-023-00484-2. NPJ Parkinsons Dis. 2023. PMID: 36973269 Free PMC article.