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Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy.
Prokopi A, Tripp CH, Tummers B, Hornsteiner F, Spoeck S, Crawford JC, Clements DR, Efremova M, Hutter K, Bellmann L, Cappellano G, Cadilha BL, Kobold S, Boon L, Ortner D, Trajanoski Z, Chen S, de Gruijl TD, Idoyaga J, Green DR, Stoitzner P. Prokopi A, et al. Among authors: clements dr. J Immunother Cancer. 2021 Jan;9(1):e000832. doi: 10.1136/jitc-2020-000832. J Immunother Cancer. 2021. PMID: 33408092 Free PMC article.
CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy.
Tadepalli S, Clements DR, Raquer-McKay HM, Lüdtke A, Saravanan S, Seong D, Vitek L, Richards CM, Carette JE, Mack M, Gottfried-Blackmore A, Graves EE, Idoyaga J. Tadepalli S, et al. Among authors: clements dr. J Exp Med. 2025 Jun 2;222(6):e20231717. doi: 10.1084/jem.20231717. Epub 2025 Mar 27. J Exp Med. 2025. PMID: 40146036 Free PMC article.
Rapid recruitment and IFN-I-mediated activation of monocytes dictate focal radiotherapy efficacy.
Tadepalli S, Clements DR, Saravanan S, Arroyo Hornero R, Lüdtke A, Blackmore B, Paulo JA, Gottfried-Blackmore A, Seong D, Park S, Chan L, Kopecky BJ, Liu Z, Ginhoux F, Lavine KJ, Murphy JP, Mack M, Graves EE, Idoyaga J. Tadepalli S, et al. Among authors: clements dr. Sci Immunol. 2023 Jun 2;8(84):eadd7446. doi: 10.1126/sciimmunol.add7446. Epub 2023 Jun 9. Sci Immunol. 2023. PMID: 37294749 Free PMC article.
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