Gygi SP - Search Results

1

Targeting oncoproteins with a positive selection assay for protein degraders.

Koduri V, Duplaquet L, Lampson BL, Wang AC, Sabet AH, Ishoey M, Paulk J, Teng M, Harris IS, Endress JE, Liu X, Dasilva E, Paulo JA, Briggs KJ, Doench JG, Ott CJ, Zhang T, Donovan KA, Fischer ES, Gygi SP, Gray NS, Bradner J, Medin JA, Buhrlage SJ, Oser MG, Kaelin WG Jr. Koduri V, et al. Among authors: gygi sp. Sci Adv. 2021 Feb 5;7(6):eabd6263. doi: 10.1126/sciadv.abd6263. Print 2021 Feb. Sci Adv. 2021. PMID: 33547076 Free PMC article.

2

Phosphorylation of RXRα mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome.

Vernia S, Lee A, Kennedy NJ, Han MS, Isasa M, Cavanagh-Kyros J, Roy A, Syed A, Chaudhry S, Edwards YJK, Gygi SP, Gao G, Davis RJ. Vernia S, et al. Among authors: gygi sp. Proc Natl Acad Sci U S A. 2022 Nov;119(44):e2210434119. doi: 10.1073/pnas.2210434119. Epub 2022 Oct 25. Proc Natl Acad Sci U S A. 2022. PMID: 36282921 Free PMC article.

3

TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.

Guarani V, Paulo J, Zhai B, Huttlin EL, Gygi SP, Harper JW. Guarani V, et al. Among authors: gygi sp. Mol Cell Biol. 2014 Mar;34(5):847-61. doi: 10.1128/MCB.01551-13. Epub 2013 Dec 16. Mol Cell Biol. 2014. PMID: 24344204 Free PMC article.

4

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.

Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q. Zheng X, et al. Among authors: gygi sp. Genes Dev. 2014 Jul 1;28(13):1429-44. doi: 10.1101/gad.242131.114. Genes Dev. 2014. PMID: 24990963 Free PMC article.

5

Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.

Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, Lim E, Liu W, Bronson RT, Bowden M, Brock J, Krop IE, Dillon DA, Gygi SP, Mills GB, Richardson AL, Signoretti S, Yaffe MB, Kaelin WG Jr. Lu G, et al. Among authors: gygi sp. Cancer Cell. 2014 Aug 11;26(2):222-34. doi: 10.1016/j.ccr.2014.06.026. Cancer Cell. 2014. PMID: 25117710 Free PMC article.

6

Effects of MEK inhibitors GSK1120212 and PD0325901 in vivo using 10-plex quantitative proteomics and phosphoproteomics.

Paulo JA, McAllister FE, Everley RA, Beausoleil SA, Banks AS, Gygi SP. Paulo JA, et al. Among authors: gygi sp. Proteomics. 2015 Jan;15(2-3):462-73. doi: 10.1002/pmic.201400154. Epub 2014 Oct 18. Proteomics. 2015. PMID: 25195567 Free PMC article.

7

A comprehensive proteomic and phosphoproteomic analysis of yeast deletion mutants of 14-3-3 orthologs and associated effects of rapamycin.

Paulo JA, Gygi SP. Paulo JA, et al. Among authors: gygi sp. Proteomics. 2015 Jan;15(2-3):474-86. doi: 10.1002/pmic.201400155. Epub 2014 Dec 17. Proteomics. 2015. PMID: 25315811 Free PMC article.

8

Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion.

Egan ES, Jiang RH, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C, Tani Y, Takahashi J, Watanabe S, Goldberg J, Paul AS, Brugnara C, Root DE, Wiegand RC, Doench JG, Duraisingh MT. Egan ES, et al. Among authors: gygi sp. Science. 2015 May 8;348(6235):711-4. doi: 10.1126/science.aaa3526. Science. 2015. PMID: 25954012 Free PMC article.

9

QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology.

Guarani V, McNeill EM, Paulo JA, Huttlin EL, Fröhlich F, Gygi SP, Van Vactor D, Harper JW. Guarani V, et al. Among authors: gygi sp. Elife. 2015 May 21;4:e06265. doi: 10.7554/eLife.06265. Elife. 2015. PMID: 25997101 Free PMC article.

10

Comprehensive Temporal Protein Dynamics during the Diauxic Shift in Saccharomyces cerevisiae.

Murphy JP, Stepanova E, Everley RA, Paulo JA, Gygi SP. Murphy JP, et al. Among authors: gygi sp. Mol Cell Proteomics. 2015 Sep;14(9):2454-65. doi: 10.1074/mcp.M114.045849. Epub 2015 Jun 15. Mol Cell Proteomics. 2015. PMID: 26077900 Free PMC article.

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