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Selenomethionine as an expressible handle for bioconjugations.
Flood DT, Hintzen JCJ, Knouse KW, Hill DE, Lu C, Cistrone PA, Chen JS, Otomo T, Dawson PE. Flood DT, et al. Among authors: chen js. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2005164118. doi: 10.1073/pnas.2005164118. Proc Natl Acad Sci U S A. 2021. PMID: 33602807 Free PMC article.
Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support.
Flood DT, Asai S, Zhang X, Wang J, Yoon L, Adams ZC, Dillingham BC, Sanchez BB, Vantourout JC, Flanagan ME, Piotrowski DW, Richardson P, Green SA, Shenvi RA, Chen JS, Baran PS, Dawson PE. Flood DT, et al. Among authors: chen js. J Am Chem Soc. 2019 Jun 26;141(25):9998-10006. doi: 10.1021/jacs.9b03774. Epub 2019 Jun 12. J Am Chem Soc. 2019. PMID: 31136164 Free PMC article.
RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis.
Flood DT, Zhang X, Fu X, Zhao Z, Asai S, Sanchez BB, Sturgell EJ, Vantourout JC, Richardson P, Flanagan ME, Piotrowski DW, Kölmel DK, Wan J, Tsai MH, Chen JS, Baran PS, Dawson PE. Flood DT, et al. Among authors: chen js. Angew Chem Int Ed Engl. 2020 May 4;59(19):7377-7383. doi: 10.1002/anie.201915493. Epub 2020 Mar 11. Angew Chem Int Ed Engl. 2020. PMID: 32050046 Free PMC article.
Synthetic Elaboration of Native DNA by RASS (SENDR).
Flood DT, Knouse KW, Vantourout JC, Kitamura S, Sanchez BB, Sturgell EJ, Chen JS, Wolan DW, Baran PS, Dawson PE. Flood DT, et al. Among authors: chen js. ACS Cent Sci. 2020 Oct 28;6(10):1789-1799. doi: 10.1021/acscentsci.0c00680. Epub 2020 Oct 5. ACS Cent Sci. 2020. PMID: 33145415 Free PMC article.
Correction to "Synthetic Elaboration of Native DNA by RASS (SENDR)".
Flood DT, Knouse KW, Vantourout JC, Kitamura S, Sanchez BB, Sturgell EJ, Chen JS, Wolan DW, Baran PS, Dawson PE. Flood DT, et al. Among authors: chen js. ACS Cent Sci. 2020 Nov 25;6(11):2117. doi: 10.1021/acscentsci.0c01389. Epub 2020 Oct 23. ACS Cent Sci. 2020. PMID: 33274288 Free PMC article.
Mild and Chemoselective Phosphorylation of Alcohols Using a Ψ-Reagent.
Ociepa M, Knouse KW, He D, Vantourout JC, Flood DT, Padial NM, Chen JS, Sanchez BB, Sturgell EJ, Zheng B, Qiu S, Schmidt MA, Eastgate MD, Baran PS. Ociepa M, et al. Among authors: chen js. Org Lett. 2021 Dec 17;23(24):9337-9342. doi: 10.1021/acs.orglett.1c02736. Epub 2021 Sep 9. Org Lett. 2021. PMID: 34499517 Free PMC article.
Design principles of the common Gly-X6-Gly membrane protein building block.
Golden K, Avarvarei C, Anderson CT, Holcomb M, Tang W, Dai X, Zhang M, Mailie CA, Sanchez BB, Chen JS, Forli S, Mravic M. Golden K, et al. Among authors: chen js. Proc Natl Acad Sci U S A. 2025 Oct 14;122(41):e2503134122. doi: 10.1073/pnas.2503134122. Epub 2025 Oct 7. Proc Natl Acad Sci U S A. 2025. PMID: 41055983
Kinetically guided radical-based synthesis of C(sp3)-C(sp3) linkages on DNA.
Wang J, Lundberg H, Asai S, Martín-Acosta P, Chen JS, Brown S, Farrell W, Dushin RG, O'Donnell CJ, Ratnayake AS, Richardson P, Liu Z, Qin T, Blackmond DG, Baran PS. Wang J, et al. Among authors: chen js. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6404-E6410. doi: 10.1073/pnas.1806900115. Epub 2018 Jun 26. Proc Natl Acad Sci U S A. 2018. PMID: 29946037 Free PMC article.
3,231 results