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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
Chessari G, Hardcastle IR, Ahn JS, Anil B, Anscombe E, Bawn RH, Bevan LD, Blackburn TJ, Buck I, Cano C, Carbain B, Castro J, Cons B, Cully SJ, Endicott JA, Fazal L, Golding BT, Griffin RJ, Haggerty K, Harnor SJ, Hearn K, Hobson S, Holvey RS, Howard S, Jennings CE, Johnson CN, Lunec J, Miller DC, Newell DR, Noble MEM, Reeks J, Revill CH, Riedinger C, St Denis JD, Tamanini E, Thomas H, Thompson NT, Vinković M, Wedge SR, Williams PA, Wilsher NE, Zhang B, Zhao Y. Chessari G, et al. Among authors: ahn js. J Med Chem. 2021 Apr 8;64(7):4071-4088. doi: 10.1021/acs.jmedchem.0c02188. Epub 2021 Mar 24. J Med Chem. 2021. PMID: 33761253
A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660).
Johnson CN, Ahn JS, Buck IM, Chiarparin E, Day JEH, Hopkins A, Howard S, Lewis EJ, Martins V, Millemaggi A, Munck JM, Page LW, Peakman T, Reader M, Rich SJ, Saxty G, Smyth T, Thompson NT, Ward GA, Williams PA, Wilsher NE, Chessari G. Johnson CN, et al. Among authors: ahn js. J Med Chem. 2018 Aug 23;61(16):7314-7329. doi: 10.1021/acs.jmedchem.8b00900. Epub 2018 Aug 9. J Med Chem. 2018. PMID: 30091600
ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth.
Ward GA, Lewis EJ, Ahn JS, Johnson CN, Lyons JF, Martins V, Munck JM, Rich SJ, Smyth T, Thompson NT, Williams PA, Wilsher NE, Wallis NG, Chessari G. Ward GA, et al. Among authors: ahn js. Mol Cancer Ther. 2018 Jul;17(7):1381-1391. doi: 10.1158/1535-7163.MCT-17-0848. Epub 2018 Apr 25. Mol Cancer Ther. 2018. PMID: 29695633
Beyond limits: a tribute to Dai-Sik Kim's academic legacy and vision.
Ahn JS, Ahn KJ, Bahk YM, Choi G, Jeong J, Jeong YG, Kang T, Kim HW, Kim RHJ, Kim S, Lee D, Lee G, Lee JW, Lee KG, Park W. Ahn JS, et al. Nanophotonics. 2025 Oct 16;14(25):4463-4478. doi: 10.1515/nanoph-2025-0394. eCollection 2025 Dec. Nanophotonics. 2025. PMID: 41424883 Free PMC article.
Sequential Lymphotoxin Beta Receptor and Retinoic Acid Receptor signals regulate cDC2 fates.
Nguyen AA, Fisher L, Ahn JSY, Zuo M, Park T, Yadav A, Gams MS, Haniuda K, Dasoveanu DC, Li C, Ward LA, Wang AA, Tayyebi Z, Trofimova D, McKee T, Mendelsohn CL, Allingham JS, Guidos CJ, Maître B, Gommerman JL, Brown CC. Nguyen AA, et al. Among authors: ahn jsy. Res Sq [Preprint]. 2025 Oct 16:rs.3.rs-4784425. doi: 10.21203/rs.3.rs-4784425/v2. Res Sq. 2025. Update in: Nat Immunol. 2025 Dec;26(12):2159-2169. doi: 10.1038/s41590-025-02329-x. PMID: 41282055 Free PMC article. Updated. Preprint.
Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate.
Nguyen AA, Fisher L, Ahn JSY, Zuo M, Park T, Yadav A, Gams MS, Haniuda K, Dasoveanu DC, Li C, Ward LA, Wang AA, Tayyebi Z, Trofimova D, McKee T, Mendelsohn CL, Allingham JS, Guidos CJ, Maître B, Gommerman JL, Brown CC. Nguyen AA, et al. Among authors: ahn jsy. Nat Immunol. 2025 Dec;26(12):2159-2169. doi: 10.1038/s41590-025-02329-x. Epub 2025 Nov 21. Nat Immunol. 2025. PMID: 41272166
1,477 results