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Page 1
Hybrid Antibiotics Targeting the Bacterial Ribosome.
Yeon SK, Pellegrino J, Raskar T, Tran MLN, Dandan M, Guérin F, Einsiedler M, Cattoir V, Fraser JS, Seiple IB. Yeon SK, et al. Among authors: fraser js. ACS Cent Sci. 2025 Sep 17;11(11):2133-2142. doi: 10.1021/acscentsci.5c01046. eCollection 2025 Nov 26. ACS Cent Sci. 2025. PMID: 41341057 Free PMC article.
Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo.
Jaishankar P, Correy GJ, Matsui Y, Togo T, Rachman MM, Stevens MGV, Hantz ER, Zheng J, Diolaiti ME, Montano M, Taha TY, Rosecrans J, Pampel J, Krogan NJ, Shoichet BK, Ashworth A, Ott M, Fraser JS, Renslo AR. Jaishankar P, et al. Among authors: fraser js. bioRxiv [Preprint]. 2025 Oct 14:2025.10.11.681833. doi: 10.1101/2025.10.11.681833. bioRxiv. 2025. PMID: 41279160 Free PMC article. Preprint.
The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2.
Suryawanshi RK, Jaishankar P, Correy GJ, Rachman MM, O'Leary PC, Taha TY, Matsui Y, Zapatero-Belinchón FJ, McCavitt-Malvido M, Doruk YU, Stevens MGV, Diolaiti ME, Jogalekar MP, Chen H, Richards AL, Kongpracha P, Bali S, Montano M, Rosecrans J, Matthay M, Togo T, Gonciarz RL, Gopalkrishnan S, Neitz RJ, Krogan NJ, Swaney DL, Shoichet BK, Ott M, Renslo AR, Ashworth A, Fraser JS. Suryawanshi RK, et al. Among authors: fraser js. Elife. 2025 Nov 19;14:RP103484. doi: 10.7554/eLife.103484. Elife. 2025. PMID: 41258893 Free PMC article.
Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space.
Ban F, Ravichandran R, Correy GJ, Herasymenko O, Silva M, Ackloo S, Bolotokova A, Chau I, Gibson E, Harding R, Hutchinson A, Loppnau P, Fraser JS, Schapira M, Cherkasov A, Gentile F. Ban F, et al. Among authors: fraser js. bioRxiv [Preprint]. 2025 Sep 9:2025.09.05.674529. doi: 10.1101/2025.09.05.674529. bioRxiv. 2025. PMID: 40964377 Free PMC article. Preprint.
Bacteriophages inhibit and evade cGAS-like immune function in bacteria.
Huiting E, Cao X, Ren J, Athukoralage JS, Luo Z, Silas S, An N, Carion H, Zhou Y, Fraser JS, Feng Y, Bondy-Denomy J. Huiting E, et al. Among authors: fraser js. Cell. 2025 Sep 4;188(18):5118. doi: 10.1016/j.cell.2025.08.009. Epub 2025 Aug 22. Cell. 2025. PMID: 40848727 Free PMC article. No abstract available.
229 results