Schardt JS - Search Results

1

Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis.

Zupancic JM, Desai AA, Schardt JS, Pornnoppadol G, Makowski EK, Smith MD, Kennedy AA, Garcia de Mattos Barbosa M, Cascalho M, Lanigan TM, Tai AW, Tessier PM. Zupancic JM, et al. Among authors: schardt js. Cell Chem Biol. 2021 Sep 16;28(9):1379-1388.e7. doi: 10.1016/j.chembiol.2021.05.019. Epub 2021 Jun 24. Cell Chem Biol. 2021. PMID: 34171229 Free PMC article.

2

IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with limited cytokine release.

Schardt JS, Walseng E, Le K, Yang C, Shah P, Fu Y, Alam K, Kelton CR, Gu Y, Huang F, Lin J, Liu W, Dippel A, Zhang H, Mulgrew K, Pryts S, Chennupati V, Chen HC, Denham J, Chen X, Pradhan P, Wu Y, Hardman C, Zhao C, Kierny M, Song Y, Dovedi SJ, Cemerski S, Mazor Y. Schardt JS, et al. MAbs. 2024 Jan-Dec;16(1):2395499. doi: 10.1080/19420862.2024.2395499. Epub 2024 Aug 28. MAbs. 2024. PMID: 39205483 Free PMC article.

3

Engineered Multivalent Nanobodies Potently and Broadly Neutralize SARS-CoV-2 Variants.

Zupancic JM, Schardt JS, Desai AA, Makowski EK, Smith MD, Pornnoppadol G, Garcia de Mattos Barbosa M, Cascalho M, Lanigan TM, Tessier PM. Zupancic JM, et al. Among authors: schardt js. Adv Ther (Weinh). 2021 Aug;4(8):2100099. doi: 10.1002/adtp.202100099. Epub 2021 Aug 2. Adv Ther (Weinh). 2021. PMID: 34514086 Free PMC article.

4

Agonist antibody discovery: Experimental, computational, and rational engineering approaches.

Schardt JS, Jhajj HS, O'Meara RL, Lwo TS, Smith MD, Tessier PM. Schardt JS, et al. Drug Discov Today. 2022 Jan;27(1):31-48. doi: 10.1016/j.drudis.2021.09.008. Epub 2021 Sep 24. Drug Discov Today. 2022. PMID: 34571277 Free PMC article. Review.

5

Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening.

Schardt JS, Pornnoppadol G, Desai AA, Park KS, Zupancic JM, Makowski EK, Smith MD, Chen H, Garcia de Mattos Barbosa M, Cascalho M, Lanigan TM, Moon JJ, Tessier PM. Schardt JS, et al. Sci Rep. 2021 Oct 20;11(1):20738. doi: 10.1038/s41598-021-99401-x. Sci Rep. 2021. PMID: 34671080 Free PMC article.

6

Improving antibody drug development using bionanotechnology.

Makowski EK, Schardt JS, Tessier PM. Makowski EK, et al. Among authors: schardt js. Curr Opin Biotechnol. 2022 Apr;74:137-145. doi: 10.1016/j.copbio.2021.10.027. Epub 2021 Dec 7. Curr Opin Biotechnol. 2022. PMID: 34890875 Free PMC article. Review.

7

Rapid and Quantitative In Vitro Evaluation of SARS-CoV-2 Neutralizing Antibodies and Nanobodies.

Wu W, Tan X, Zupancic J, Schardt JS, Desai AA, Smith MD, Zhang J, Xie L, Oo MK, Tessier PM, Fan X. Wu W, et al. Among authors: schardt js. Anal Chem. 2022 Mar 15;94(10):4504-4512. doi: 10.1021/acs.analchem.2c00062. Epub 2022 Mar 3. Anal Chem. 2022. PMID: 35238533 Free PMC article.

8

Mutational analysis of SARS-CoV-2 variants of concern reveals key tradeoffs between receptor affinity and antibody escape.

Makowski EK, Schardt JS, Smith MD, Tessier PM. Makowski EK, et al. Among authors: schardt js. PLoS Comput Biol. 2022 May 31;18(5):e1010160. doi: 10.1371/journal.pcbi.1010160. eCollection 2022 May. PLoS Comput Biol. 2022. PMID: 35639784 Free PMC article.

9

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space.

Makowski EK, Kinnunen PC, Huang J, Wu L, Smith MD, Wang T, Desai AA, Streu CN, Zhang Y, Zupancic JM, Schardt JS, Linderman JJ, Tessier PM. Makowski EK, et al. Among authors: schardt js. Nat Commun. 2022 Jul 1;13(1):3788. doi: 10.1038/s41467-022-31457-3. Nat Commun. 2022. PMID: 35778381 Free PMC article.

10

Optimization of therapeutic antibodies for reduced self-association and non-specific binding via interpretable machine learning.

Makowski EK, Wang T, Zupancic JM, Huang J, Wu L, Schardt JS, De Groot AS, Elkins SL, Martin WD, Tessier PM. Makowski EK, et al. Among authors: schardt js. Nat Biomed Eng. 2024 Jan;8(1):45-56. doi: 10.1038/s41551-023-01074-6. Epub 2023 Sep 4. Nat Biomed Eng. 2024. PMID: 37666923 Free PMC article.

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