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Rapid and robust cysteine bioconjugation with vinylheteroarenes.
Seki H, Walsh SJ, Bargh JD, Parker JS, Carroll J, Spring DR. Seki H, et al. Among authors: spring dr. Chem Sci. 2021 Jun 7;12(26):9060-9068. doi: 10.1039/d1sc02722k. eCollection 2021 Jul 7. Chem Sci. 2021. PMID: 34276935 Free PMC article.
Specific inhibition of CK2α from an anchor outside the active site.
Brear P, De Fusco C, Hadje Georgiou K, Francis-Newton NJ, Stubbs CJ, Sore HF, Venkitaraman AR, Abell C, Spring DR, Hyvönen M. Brear P, et al. Among authors: spring dr. Chem Sci. 2016 Nov 1;7(11):6839-6845. doi: 10.1039/c6sc02335e. Epub 2016 Jul 12. Chem Sci. 2016. PMID: 28451126 Free PMC article.
A new Pseudomonas quinolone signal (PQS) binding partner: MexG.
Hodgkinson JT, Gross J, Baker YR, Spring DR, Welch M. Hodgkinson JT, et al. Among authors: spring dr. Chem Sci. 2016 Apr 21;7(4):2553-2562. doi: 10.1039/c5sc04197j. Epub 2016 Jan 20. Chem Sci. 2016. PMID: 28660026 Free PMC article.
Second-generation CK2α inhibitors targeting the αD pocket.
Iegre J, Brear P, De Fusco C, Yoshida M, Mitchell SL, Rossmann M, Carro L, Sore HF, Hyvönen M, Spring DR. Iegre J, et al. Among authors: spring dr. Chem Sci. 2018 Feb 20;9(11):3041-3049. doi: 10.1039/c7sc05122k. eCollection 2018 Mar 21. Chem Sci. 2018. PMID: 29732088 Free PMC article.
Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.
Wu Y, Kaur A, Fowler E, Wiedmann MM, Young R, Galloway WRJD, Olsen L, Sore HF, Chattopadhyay A, Kwan TT, Xu W, Walsh SJ, de Andrade P, Janecek M, Arumugam S, Itzhaki LS, Lau YH, Spring DR. Wu Y, et al. Among authors: spring dr. ACS Chem Biol. 2019 Mar 15;14(3):526-533. doi: 10.1021/acschembio.9b00063. Epub 2019 Feb 7. ACS Chem Biol. 2019. PMID: 30702850
233 results