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53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.
Ghezraoui H, Oliveira C, Becker JR, Bilham K, Moralli D, Anzilotti C, Fischer R, Deobagkar-Lele M, Sanchiz-Calvo M, Fueyo-Marcos E, Bonham S, Kessler BM, Rottenberg S, Cornall RJ, Green CM, Chapman JR. Ghezraoui H, et al. Among authors: becker jr. Nature. 2018 Aug;560(7716):122-127. doi: 10.1038/s41586-018-0362-1. Epub 2018 Jul 25. Nature. 2018. PMID: 30046110 Free PMC article.
Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice.
King A, Reichl P, Metson JS, Parker R, Munro D, Oliveira C, Becker JR, Biggs D, Preece C, Davies B, Chapman JR. King A, et al. Among authors: becker jr. bioRxiv [Preprint]. 2023 Dec 21:2023.12.20.572534. doi: 10.1101/2023.12.20.572534. bioRxiv. 2023. Update in: Nat Struct Mol Biol. 2025 Jan;32(1):86-97. doi: 10.1038/s41594-024-01381-9. PMID: 38187711 Free PMC article. Updated. Preprint.
Targeting Cardiomyocyte PCNA and POLD1 Prevents Pathologic Myocardial Hypertrophy.
Pal S, Glennon MS, Nixon BR, Chetkof EJ, Shridhar P, Kathiresan CM, Glasser MB, Waldron CJ, Guo L, Clavere NG, Banerjee D, Kim JH, Becker JR. Pal S, et al. Among authors: becker jr. Circ Res. 2025 Oct 10;137(9):1160-1181. doi: 10.1161/CIRCRESAHA.124.325647. Epub 2025 Sep 15. Circ Res. 2025. PMID: 40948130 Free PMC article.
Proteomic Analysis of Valsartan for Attenuating Disease Evolution in Early Sarcomeric Hypertrophic Cardiomyopathy (VANISH) Clinical Trial.
Topriceanu CC, Vissing CR, Axelsson Raja A, Day SM, Russell MW, Zahka K, Pereira AC, Colan SD, Murphy AM, Canter C, Bach RG, Wheeler MT, Rossano JW, Owens AT, Mestroni L, Taylor MRG, Moon JC, Captur G, Patel AR, Wilmot I, Soslow JH, Becker JR, Seidman CE, Lakdawala NK, Bundgaard H, Tahir UA, Ho CY. Topriceanu CC, et al. Among authors: becker jr. Circ Heart Fail. 2025 Jun;18(6):e012393. doi: 10.1161/CIRCHEARTFAILURE.124.012393. Epub 2025 May 9. Circ Heart Fail. 2025. PMID: 40340372 Clinical Trial.
170 results