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The Interleukin-1 Receptor-Associated Kinase 4 Inhibitor PF-06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial.
Winkler A, Sun W, De S, Jiao A, Sharif MN, Symanowicz PT, Athale S, Shin JH, Wang J, Jacobson BA, Ramsey SJ, Dower K, Andreyeva T, Liu H, Hegen M, Homer BL, Brodfuehrer J, Tilley M, Gilbert SA, Danto SI, Beebe JJ, Barnes BJ, Pascual V, Lin LL, Kilty I, Fleming M, Rao VR. Winkler A, et al. Among authors: sharif mn. Arthritis Rheumatol. 2021 Dec;73(12):2206-2218. doi: 10.1002/art.41953. Epub 2021 Nov 1. Arthritis Rheumatol. 2021. PMID: 34423919 Free PMC article. Clinical Trial.
Soluble Fn14 Is Detected and Elevated in Mouse and Human Kidney Disease.
Sharif MN, Campanholle G, Nagiec EE, Wang J, Syed J, O'Neil SP, Zhan Y, Brenneman K, Homer B, Neubert H, Karim R, Pullen N, Evans SM, Fleming M, Chockalingam P, Lin LL. Sharif MN, et al. PLoS One. 2016 May 12;11(5):e0155368. doi: 10.1371/journal.pone.0155368. eCollection 2016. PLoS One. 2016. PMID: 27171494 Free PMC article.
PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor.
Xu H, Jesson MI, Seneviratne UI, Lin TH, Sharif MN, Xue L, Nguyen C, Everley RA, Trujillo JI, Johnson DS, Point GR, Thorarensen A, Kilty I, Telliez JB. Xu H, et al. Among authors: sharif mn. ACS Chem Biol. 2019 Jun 21;14(6):1235-1242. doi: 10.1021/acschembio.9b00188. Epub 2019 May 22. ACS Chem Biol. 2019. PMID: 31082193
Ligand non-competitive GITR antibody prevents formation of the obligatory signal-triggering GITRL: GITR stoichiometry.
Yan J, Min-DeBartolo J, Huang CS, Sharif MN, Li L, Fish S, Dower C, Murphy D, Andreyeva T, Liu H, Han X, Zheng W, Ooi JH, Edmonds J, Chen T, Maben Z, Stevens CR, Goihberg P, Nocula-Lugowska M, Evans SM, Mosyak L, Kelleher K, Dickinson C, Hegen M, Winkler A, Karlsson F. Yan J, et al. Among authors: sharif mn. Sci Rep. 2025 Dec 18. doi: 10.1038/s41598-025-32541-6. Online ahead of print. Sci Rep. 2025. PMID: 41413164 Free article.
39 results