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Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity.
Si L, Bai H, Oh CY, Zhang T, Hong F, Jiang A, Ye Y, Jordan TX, Logue J, McGrath M, Belgur C, Nurani A, Cao W, Prantil-Baun R, Gygi SP, Powers RK, Frieman M, tenOever BR, Ingber DE. Si L, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2021 Nov 22:2021.11.19.469183. doi: 10.1101/2021.11.19.469183. bioRxiv. 2021. Update in: Mol Ther Nucleic Acids. 2022 Sep 13;29:923-940. doi: 10.1016/j.omtn.2022.08.031. PMID: 34845453 Free PMC article. Updated. Preprint.
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.
Mitchell W, Goeminne LJE, Tyshkovskiy A, Zhang S, Chen JY, Paulo JA, Pierce KA, Choy AH, Clish CB, Gygi SP, Gladyshev VN. Mitchell W, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2023 Nov 27:2023.06.30.546730. doi: 10.1101/2023.06.30.546730. bioRxiv. 2023. Update in: Elife. 2024 Mar 22;12:RP90579. doi: 10.7554/eLife.90579. PMID: 37425825 Free PMC article. Updated. Preprint.
Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST.
Kraus F, He Y, Swarup S, Overmyer KA, Jiang Y, Brenner J, Capitanio C, Bieber A, Jen A, Nightingale NM, Anderson BJ, Lee C, Paulo JA, Smith IR, Plitzko JM, Gygi SP, Schulman BA, Wilfling F, Coon JJ, Harper JW. Kraus F, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2024 Oct 20:2024.03.26.586828. doi: 10.1101/2024.03.26.586828. bioRxiv. 2024. Update in: Sci Adv. 2025 Jan 24;11(4):eadu5787. doi: 10.1126/sciadv.adu5787. PMID: 38585873 Free PMC article. Updated. Preprint.
Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST.
Sprenger HG, Mittenbühler MJ, Sun Y, Van Vranken JG, Schindler S, Jayaraj A, Khetarpal SA, Vargas-Castillo A, Puszynska AM, Spinelli JB, Armani A, Kunchok T, Ryback B, Seo HS, Song K, Sebastian L, O'Young C, Braithwaite C, Dhe-Paganon S, Burger N, Mills EL, Gygi SP, Arthanari H, Chouchani ET, Sabatini DM, Spiegelman BM. Sprenger HG, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2024 Apr 10:2024.04.10.588849. doi: 10.1101/2024.04.10.588849. bioRxiv. 2024. Update in: Cell Metab. 2025 Apr 01;37(4):857-869.e9. doi: 10.1016/j.cmet.2025.01.024. PMID: 38645260 Free PMC article. Updated. Preprint.
CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias.
Fleming TJ, Antoszewski M, Lambo S, Gundry MC, Piussi R, Wahlster L, Shah S, Reed FE, Dong KD, Paulo JA, Gygi SP, Mimoso C, Goldman SR, Adelman K, Perry JA, Pikman Y, Stegmaier K, Barrachina MN, Machlus KR, Hovestadt V, Arruda A, Minden MD, Voit RA, Sankaran VG. Fleming TJ, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2024 Dec 30:2024.12.30.630680. doi: 10.1101/2024.12.30.630680. bioRxiv. 2024. Update in: Blood. 2025 Sep 24:blood.2025028954. doi: 10.1182/blood.2025028954. PMID: 39803492 Free PMC article. Updated. Preprint.
769 results