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Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.
Loreto A, Angeletti C, Gu W, Osborne A, Nieuwenhuis B, Gilley J, Merlini E, Arthur-Farraj P, Amici A, Luo Z, Hartley-Tassell L, Ve T, Desrochers LM, Wang Q, Kobe B, Orsomando G, Coleman MP. Loreto A, et al. Among authors: merlini e. Elife. 2021 Dec 6;10:e72823. doi: 10.7554/eLife.72823. Elife. 2021. PMID: 34870595 Free PMC article.
Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain.
Feldman HC, Merlini E, Guijas C, DeMeester KE, Njomen E, Kozina EM, Yokoyama M, Vinogradova E, Reardon HT, Melillo B, Schreiber SL, Loreto A, Blankman JL, Cravatt BF. Feldman HC, et al. Among authors: merlini e. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2208457119. doi: 10.1073/pnas.2208457119. Epub 2022 Aug 22. Proc Natl Acad Sci U S A. 2022. PMID: 35994671 Free PMC article.
SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides.
Loreto A, Cramb KML, McDermott LA, Antoniou C, Cirilli I, Caiazza MC, Merlini E, Arthur-Farraj P, du Preez WD, Mock ED, Zhao HT, Bennett DL, Orsomando G, Coleman MP, Wade-Martins R. Loreto A, et al. Among authors: merlini e. Neurobiol Dis. 2025 Sep;213:106986. doi: 10.1016/j.nbd.2025.106986. Epub 2025 Jun 3. Neurobiol Dis. 2025. PMID: 40473123 Free PMC article.
87 results