Design of Potent Menin-KMT2A Interaction Inhibitors with Improved In Vitro ADME Properties and Reduced hERG Affinity.
Chapsal BD, Kimbrough JR, Bester SM, Bergstrom A, Backos DS, Campos B, McDonald MG, Abrahamsen R, Allen AC, Doerner Barbour PM, Bettendorf T, Boys ML, Brown K, Chicarelli MJ, Cook AW, Crooks AL, Cruz CL, Dahlke JR, Eide A, Fell JB, Fulton JL, Gargus M, Gaudino JJ, Guarnieri AL, Hansen EP, Holt MC, Kahn DR, Laird ER, Larsen PD, Linwood R, Martinson MC, McCown J, Mejia MJ, Moreno DA, Mou TC, Newhouse B, O'Leary JM, Rodriguez ME, Singh A, Sinik L, Strand KA, Touney EE, Wollenberg LA, Wong J, Zhou Y, Fischer JP, Allen S.
Chapsal BD, et al. Among authors: cook aw.
ACS Med Chem Lett. 2024 Dec 31;16(2):224-233. doi: 10.1021/acsmedchemlett.4c00311. eCollection 2025 Feb 13.
ACS Med Chem Lett. 2024.
PMID: 39967615