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DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.
Willemsen L, Prange KHM, Neele AE, van Roomen CPAA, Gijbels M, Griffith GR, Toom MD, Beckers L, Siebeler R, Spann NJ, Chen HJ, Bosmans LA, Gorbatenko A, van Wouw S, Zelcer N, Jacobs H, van Leeuwen F, de Winther MPJ. Willemsen L, et al. Among authors: van leeuwen f, van roomen cpaa, van wouw s. Cell Rep. 2022 Nov 22;41(8):111703. doi: 10.1016/j.celrep.2022.111703. Cell Rep. 2022. PMID: 36417856 Free article.
Progressive methylation of ageing histones by Dot1 functions as a timer.
De Vos D, Frederiks F, Terweij M, van Welsem T, Verzijlbergen KF, Iachina E, de Graaf EL, Altelaar AF, Oudgenoeg G, Heck AJ, Krijgsveld J, Bakker BM, van Leeuwen F. De Vos D, et al. Among authors: van leeuwen f, van welsem t. EMBO Rep. 2011 Sep 1;12(9):956-62. doi: 10.1038/embor.2011.131. EMBO Rep. 2011. PMID: 21760613 Free PMC article.
Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo.
Vlaming H, van Welsem T, de Graaf EL, Ontoso D, Altelaar AF, San-Segundo PA, Heck AJ, van Leeuwen F. Vlaming H, et al. Among authors: van leeuwen f, van welsem t. EMBO Rep. 2014 Oct;15(10):1077-84. doi: 10.15252/embr.201438793. Epub 2014 Aug 20. EMBO Rep. 2014. PMID: 25141862 Free PMC article.
Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism.
van Welsem T, Korthout T, Ekkebus R, Morais D, Molenaar TM, van Harten K, Poramba-Liyanage DW, Sun SM, Lenstra TL, Srivas R, Ideker T, Holstege FCP, van Attikum H, El Oualid F, Ovaa H, Stulemeijer IJE, Vlaming H, van Leeuwen F. van Welsem T, et al. Among authors: van leeuwen f, van harten k, van attikum h. Nucleic Acids Res. 2018 Nov 30;46(21):11251-11261. doi: 10.1093/nar/gky801. Nucleic Acids Res. 2018. PMID: 30203048 Free PMC article.
Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.
Vlaming H, McLean CM, Korthout T, Alemdehy MF, Hendriks S, Lancini C, Palit S, Klarenbeek S, Kwesi-Maliepaard EM, Molenaar TM, Hoekman L, Schmidlin TT, Altelaar AM, van Welsem T, Dannenberg JH, Jacobs H, van Leeuwen F. Vlaming H, et al. Among authors: van leeuwen f, van welsem t. EMBO J. 2019 Jul 15;38(14):e101564. doi: 10.15252/embj.2019101564. Epub 2019 Jun 17. EMBO J. 2019. PMID: 31304633 Free PMC article.
1,249 results