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Self-amplifying RNA vaccine protects mice against lethal Ebola virus infection.
Krähling V, Erbar S, Kupke A, Nogueira SS, Walzer KC, Berger H, Dietzel E, Halwe S, Rohde C, Sauerhering L, Aragão-Santiago L, Moreno Herrero J, Witzel S, Haas H, Becker S, Sahin U. Krähling V, et al. Among authors: sahin u. Mol Ther. 2023 Feb 1;31(2):374-386. doi: 10.1016/j.ymthe.2022.10.011. Epub 2022 Oct 27. Mol Ther. 2023. PMID: 36303436 Free PMC article.
Reverse-phase chromatography removes double-stranded RNA, fragments, and residual template to decrease immunogenicity and increase cell potency of mRNA and saRNA.
Krušič A, Mencin N, Leban M, Nett E, Perković M, Sahin U, Megušar P, Štrancar A, Sekirnik R. Krušič A, et al. Among authors: sahin u. Mol Ther Nucleic Acids. 2025 Feb 22;36(2):102491. doi: 10.1016/j.omtn.2025.102491. eCollection 2025 Jun 10. Mol Ther Nucleic Acids. 2025. PMID: 40166612 Free PMC article.
Reducing cell intrinsic immunity to mRNA vaccine alters adaptive immune responses in mice.
Wang Z, Jacobus EJ, Stirling DC, Krumm S, Flight KE, Cunliffe RF, Mottl J, Singh C, Mosscrop LG, Santiago LA, Vogel AB, Kariko K, Sahin U, Erbar S, Tregoning JS. Wang Z, et al. Among authors: sahin u. Mol Ther Nucleic Acids. 2023 Oct 5;34:102045. doi: 10.1016/j.omtn.2023.102045. eCollection 2023 Dec 12. Mol Ther Nucleic Acids. 2023. PMID: 37876532 Free PMC article.
Hybrid core-shell particles for mRNA systemic delivery.
Andretto V, Repellin M, Pujol M, Almouazen E, Sidi-Boumedine J, Granjon T, Zhang H, Remaut K, Jordheim LP, Briançon S, Keil IS, Vascotto F, Walzer KC, Sahin U, Haas H, Kryza D, Lollo G. Andretto V, et al. Among authors: sahin u. J Control Release. 2023 Jan;353:1037-1049. doi: 10.1016/j.jconrel.2022.11.042. Epub 2022 Dec 22. J Control Release. 2023. PMID: 36442614 Free article.
543 results