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Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen.
Tong Y, Baker KA, Chapman AM, Elsen NL, Fowler F, George MD, Gesmundo NJ, Hatton H, Hickey M, Hutchins CW, Jeffries CL, Kelly A, Korepanova A, Miller IR, Nocek B, Panchal SC, Pemberton OA, Qiu W, Talaty NN, Hin Tang HY, Towne D, Zhang M, Zhao Y, Gopalakrishnan SM, Sun C, Kort ME, Dart MJ, Firestone AJ. Tong Y, et al. Among authors: gopalakrishnan sm. J Med Chem. 2025 Jun 26;68(12):12434-12456. doi: 10.1021/acs.jmedchem.4c03029. Epub 2025 Jun 5. J Med Chem. 2025. PMID: 40472162
Collaborative robotics to enable ultra-high-throughput IR-MALDESI.
Shanley J, Pu F, Williams JD, Elsen NL, Gopalakrishnan SM, Pan JY, Radosevich AJ. Shanley J, et al. Among authors: gopalakrishnan sm. SLAS Technol. 2024 Aug;29(4):100163. doi: 10.1016/j.slast.2024.100163. Epub 2024 Jul 23. SLAS Technol. 2024. PMID: 39047813 Free article.
New Platform for Label-Free, Proximal Cellular Pharmacodynamic Assays: Identification of Glutaminase Inhibitors Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry.
Pu F, Radosevich AJ, Bruckner BG, Fontaine DA, Panchal SC, Williams JD, Gopalakrishnan SM, Elsen NL. Pu F, et al. Among authors: gopalakrishnan sm. ACS Chem Biol. 2023 Apr 21;18(4):942-948. doi: 10.1021/acschembio.3c00087. Epub 2023 Apr 12. ACS Chem Biol. 2023. PMID: 37043689
Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo.
Randolph JT, O'Connor MJ, Han F, Hutchins CW, Siu YA, Cho M, Zheng Y, Hickson JA, Markley JL, Manaves V, Algire M, Baker KA, Chapman AM, Gopalakrishnan SM, Panchal SC, Foster-Duke K, Stolarik DF, Kempf-Grote A, Dammeier D, Fossey S, Sun Q, Sun C, Shen Y, Dart MJ, Kati WM, Lai A, Firestone AJ, Kort ME. Randolph JT, et al. Among authors: gopalakrishnan sm. J Med Chem. 2023 Mar 23;66(6):3852-3865. doi: 10.1021/acs.jmedchem.2c01415. Epub 2023 Mar 6. J Med Chem. 2023. PMID: 36877935
Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Goedken ER, Argiriadi MA, Dietrich JD, Petros AM, Krishnan N, Panchal SC, Qiu W, Wu H, Zhu H, Adams AM, Bodelle PM, Goguen L, Richardson PL, Slivka PF, Srikumaran M, Upadhyay AK, Wu B, Judge RA, Vasudevan A, Gopalakrishnan SM, Cox PB, Stoll VS, Sun C. Goedken ER, et al. Among authors: gopalakrishnan sm. Sci Rep. 2022 Aug 26;12(1):14561. doi: 10.1038/s41598-022-18760-1. Sci Rep. 2022. PMID: 36028520 Free PMC article.
40 results