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Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP-1 Transcription Factor ΔFOSB.
McNeme S, Yim YY, Kumar A, Li Y, Hughes B, St Romain CP, Aglyamova G, Chen J, Nguyen ND, Fan S, Stephens GS, Zhao WN, Kruzshak S, Estill M, Brener C, Tofani S, Kumar A, Chen EP, Takatka N, Robison AJ, Chen H, Powell RT, Haggarty SJ, Stephan C, Nestler EJ, Chin J, Machius M, Zhou J, Rudenko G. McNeme S, et al. Among authors: robison aj. J Biol Chem. 2025 Dec 22:111080. doi: 10.1016/j.jbc.2025.111080. Online ahead of print. J Biol Chem. 2025. PMID: 41443415 Free article.
Efficient in vivo pharmacological inhibition of ΔFOSB, an AP1 transcription factor, in brain.
McNeme S, Kumar A, Yim YY, Hughes BW, St Romain C, Li Y, Kumar A, Bao Q, Estill M, Fan S, Takatka N, Chen EP, Rivera M, Chen H, Robison AJ, Machius M, Haggarty SJ, Chin J, Nestler EJ, Zhou J, Rudenko G. McNeme S, et al. Among authors: robison aj. bioRxiv [Preprint]. 2025 Oct 23:2025.10.21.683721. doi: 10.1101/2025.10.21.683721. bioRxiv. 2025. PMID: 41280056 Free PMC article. Preprint.
Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor ΔFOSB.
McNeme S, Yim YY, Kumar A, Li Y, Hughes B, St Romain CP, Aglyamova G, Chen J, Nguyen ND, Fan S, Stephens GS, Zhao WN, Kruzshak S, Estill M, Brener C, Tofani S, Kumar A, Chen EP, Takatka N, Robison AJ, Chen H, Powell RT, Haggarty SJ, Stephan C, Nestler EJ, Chin J, Machius M, Zhou J, Rudenko G. McNeme S, et al. Among authors: robison aj. bioRxiv [Preprint]. 2025 Oct 23:2025.10.21.683675. doi: 10.1101/2025.10.21.683675. bioRxiv. 2025. Update in: J Biol Chem. 2025 Dec 22:111080. doi: 10.1016/j.jbc.2025.111080. PMID: 41279307 Free PMC article. Updated. Preprint.
180 results