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Page 1
Chemoproteomic Profiling of C. albicans for Characterization of Antifungal Kinase Inhibitors.
Shirley DJ, Nandakumar M, Cabrera A, Yiu B, Puumala E, Liu Z, Robbins N, Whitesell L, Smith JL, Lyons S, Mordant AL, Herring LE, Graves LM, Couñago RM, Drewry DH, Cowen LE, Willson TM. Shirley DJ, et al. Among authors: puumala e. J Med Chem. 2025 Apr 10;68(7):7615-7629. doi: 10.1021/acs.jmedchem.5c00097. Epub 2025 Mar 20. J Med Chem. 2025. PMID: 40110855 Free PMC article.
Structure-guided optimization of small molecules targeting the yeast casein kinase, Yck2, as a therapeutic strategy to combat Candida albicans.
Cowen L, Puumala E, Nandakumar M, Yiu B, Stogios P, Strickland B, Zarnowski R, Wang X, Williams N, Savchenko A, Andes D, Robbins N, Whitesell L, Willson T. Cowen L, et al. Among authors: puumala e. Res Sq [Preprint]. 2025 Jan 8:rs.3.rs-5524306. doi: 10.21203/rs.3.rs-5524306/v1. Res Sq. 2025. Update in: Nat Commun. 2025 Mar 04;16(1):2156. doi: 10.1038/s41467-025-57346-z. PMID: 39866870 Free PMC article. Updated. Preprint.
Chemoproteomic Profiling of C. albicans for Characterization of Anti-fungal Kinase Inhibitors.
Shirley DJ, Nandakumar M, Cabrera A, Yiu B, Puumala E, Liu Z, Robbins N, Whitesell L, Smith JL, Lyons SP, Mordant AL, Herring LE, Graves LM, Couñago RM, Drewry DH, Cowen LE, Willson TM. Shirley DJ, et al. Among authors: puumala e. bioRxiv [Preprint]. 2025 Jan 10:2025.01.10.632200. doi: 10.1101/2025.01.10.632200. bioRxiv. 2025. Update in: J Med Chem. 2025 Apr 10;68(7):7615-7629. doi: 10.1021/acs.jmedchem.5c00097. PMID: 39829896 Free PMC article. Updated. Preprint.
Butyrolactol A potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition.
Chen X, Diessel Duan H, Hoy MJ, Koteva K, Spitzer M, Guitor AK, Puumala E, Fiebig AA, Hu G, Yiu B, Chou S, Bian Z, Choi Y, Guo ABY, Wang W, Sun S, Robbins N, Averette AF, Cook MA, Truant R, MacNeil LT, Brown ED, Kronstad JW, Coombes BK, Cowen LE, Heitman J, Li H, Wright GD. Chen X, et al. Among authors: puumala e. bioRxiv [Preprint]. 2025 Jul 29:2025.01.06.630955. doi: 10.1101/2025.01.06.630955. bioRxiv. 2025. PMID: 39829750 Free PMC article. Preprint.
Cyprocide selectively kills nematodes via cytochrome P450 bioactivation.
Knox J, Burns AR, Cooke B, Cammalleri SR, Kitner M, Ching J, Castelli JMP, Puumala E, Snider J, Koury E, Collins JB, Geissah S, Dowling JJ, Andersen EC, Stagljar I, Cowen LE, Lautens M, Zasada I, Roy PJ. Knox J, et al. Among authors: puumala e. Nat Commun. 2024 Jul 2;15(1):5529. doi: 10.1038/s41467-024-49738-4. Nat Commun. 2024. PMID: 38956039 Free PMC article.
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