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Page 1
Preclinical immunogenicity and protective efficacy of a SARS-CoV-2 RBD-based vaccine produced with the thermophilic filamentous fungal expression system Thermothelomyces heterothallica C1.
Gonzalez-Hernandez M, Kaiser FK, Steffen I, Ciurkiewicz M, van Amerongen G, Tchelet R, Emalfarb M, Saloheimo M, Wiebe MG, Vitikainen M, Albulescu IC, Bosch BJ, Baumgärtner W, Haagmans BL, Osterhaus ADME. Gonzalez-Hernandez M, et al. Among authors: vitikainen m. Front Immunol. 2023 Jun 9;14:1204834. doi: 10.3389/fimmu.2023.1204834. eCollection 2023. Front Immunol. 2023. PMID: 37359531 Free PMC article.
Penicillin-binding protein folding is dependent on the PrsA peptidyl-prolyl cis-trans isomerase in Bacillus subtilis.
Hyyryläinen HL, Marciniak BC, Dahncke K, Pietiäinen M, Courtin P, Vitikainen M, Seppala R, Otto A, Becher D, Chapot-Chartier MP, Kuipers OP, Kontinen VP. Hyyryläinen HL, et al. Among authors: vitikainen m. Mol Microbiol. 2010 Jul 1;77(1):108-27. doi: 10.1111/j.1365-2958.2010.07188.x. Epub 2010 May 4. Mol Microbiol. 2010. PMID: 20487272 Free article.
Detecting novel genes with sparse arrays.
Arvas M, Haiminen N, Smit B, Rautio J, Vitikainen M, Wiebe M, Martinez D, Chee C, Kunkel J, Sanchez C, Nelson MA, Pakula T, Saloheimo M, Penttilä M, Kivioja T. Arvas M, et al. Among authors: vitikainen m. Gene. 2010 Nov 1;467(1-2):41-51. doi: 10.1016/j.gene.2010.07.009. Epub 2010 Aug 5. Gene. 2010. PMID: 20691772 Free PMC article.
In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI-MS spectrum.
Espinosa LA, Ramos Y, Andújar I, Torres EO, Cabrera G, Martín A, Roche D, Chinea G, Becquet M, González I, Canaán-Haden C, Nelson E, Rojas G, Pérez-Massón B, Pérez-Martínez D, Boggiano T, Palacio J, Lozada Chang SL, Hernández L, de la Luz Hernández KR, Markku S, Vitikainen M, Valdés-Balbín Y, Santana-Medero D, Rivera DG, Vérez-Bencomo V, Emalfarb M, Tchelet R, Guillén G, Limonta M, Pimentel E, Ayala M, Besada V, González LJ. Espinosa LA, et al. Among authors: vitikainen m. Anal Bioanal Chem. 2021 Dec;413(30):7559-7585. doi: 10.1007/s00216-021-03721-w. Epub 2021 Nov 5. Anal Bioanal Chem. 2021. PMID: 34739558 Free PMC article.
A recombinant SARS-CoV-2 receptor-binding domain expressed in an engineered fungal strain of Thermothelomyces heterothallica induces a functional immune response in mice.
Lazo L, Bequet-Romero M, Lemos G, Musacchio A, Cabrales A, Bruno AJ, Ariel Espinosa L, Saloheimo M, Vitikainen M, Hernández A, Emalfarb M, Tchelet R, Suzarte E, Guillén G. Lazo L, et al. Among authors: vitikainen m. Vaccine. 2022 Feb 16;40(8):1162-1169. doi: 10.1016/j.vaccine.2022.01.007. Epub 2022 Jan 19. Vaccine. 2022. PMID: 35078661 Free PMC article.
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