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Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α.
A M, Wales TE, Zhou H, Draga-Coletă SV, Gorgulla C, Blackmore KA, Mittenbühler MJ, Kim CR, Bogoslavski D, Zhang Q, Wang ZF, Jedrychowski MP, Seo HS, Song K, Xu AZ, Sebastian L, Gygi SP, Arthanari H, Dhe-Paganon S, Griffin PR, Engen JR, Spiegelman BM. A M, et al. Mol Cell. 2023 Jun 1;83(11):1903-1920.e12. doi: 10.1016/j.molcel.2023.05.008. Mol Cell. 2023. PMID: 37267907 Free PMC article.
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle.
Vargas-Castillo A, Sun Y, Smythers AL, Grauvogel L, Dumesic PA, Emont MP, Tsai LT, Rosen ED, Zammit NW, Shaffer SM, Ordonez M, Chouchani ET, Gygi SP, Wang T, Sharma AK, Balaz M, Wolfrum C, Spiegelman BM. Vargas-Castillo A, et al. Cell Metab. 2024 Sep 3;36(9):2146-2155.e5. doi: 10.1016/j.cmet.2024.07.002. Epub 2024 Jul 30. Cell Metab. 2024. PMID: 39084217 Free PMC article.
Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance.
Gao X, Wu Y, Chick JM, Abbott A, Jiang B, Wang DJ, Comte-Walters S, Johnson RH, Oberholtzer N, Nishimura MI, Gygi SP, Mehta A, Guttridge DC, Ball L, Mehrotra S, Sicinski P, Yu XZ, Wang H. Gao X, et al. Cell Rep. 2023 Apr 25;42(4):112314. doi: 10.1016/j.celrep.2023.112314. Epub 2023 Mar 30. Cell Rep. 2023. PMID: 37000627 Free PMC article.
Global and tissue-specific aging effects on murine proteomes.
Keele GR, Zhang JG, Szpyt J, Korstanje R, Gygi SP, Churchill GA, Schweppe DK. Keele GR, et al. Cell Rep. 2023 Jul 25;42(7):112715. doi: 10.1016/j.celrep.2023.112715. Epub 2023 Jul 4. Cell Rep. 2023. PMID: 37405913 Free PMC article.
A disordered region controls cBAF activity via condensation and partner recruitment.
Patil A, Strom AR, Paulo JA, Collings CK, Ruff KM, Shinn MK, Sankar A, Cervantes KS, Wauer T, St Laurent JD, Xu G, Becker LA, Gygi SP, Pappu RV, Brangwynne CP, Kadoch C. Patil A, et al. Cell. 2023 Oct 26;186(22):4936-4955.e26. doi: 10.1016/j.cell.2023.08.032. Epub 2023 Oct 3. Cell. 2023. PMID: 37788668 Free PMC article.
Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming.
Zhao T, He L, Wong LP, Mei S, Xia J, Xu Y, Van Vranken JG, Mazzola M, Chen L, Rhee C, Fang T, Fukushima T, Sayles LC, Diaz M, Gibbons JAB, Mostoslavsky R, Gygi SP, Dou Z, Sykes DB, Sadreyev RI, Sweet-Cordero EA, Scadden DT. Zhao T, et al. Cell Metab. 2025 Aug 5;37(8):1667-1681.e13. doi: 10.1016/j.cmet.2025.05.009. Epub 2025 Jun 11. Cell Metab. 2025. PMID: 40505660
Insulin sensitization by small molecules enhancing GLUT4 translocation.
Yin TC, Van Vranken JG, Srivastava D, Mittal A, Buscaglia P, Moore AE, Verdinez JA, Graham AE, Walsh SA, Acevedo MA, Kerns RJ, Artemyev NO, Gygi SP, Sebag JA. Yin TC, et al. Cell Chem Biol. 2023 Aug 17;30(8):933-942.e6. doi: 10.1016/j.chembiol.2023.06.012. Epub 2023 Jul 14. Cell Chem Biol. 2023. PMID: 37453421 Free PMC article.
769 results