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Page 1
In Silico Clinical Trials: Is It Possible?
Arsène S, Parès Y, Tixier E, Granjeon-Noriot S, Martin B, Bruezière L, Couty C, Courcelles E, Kahoul R, Pitrat J, Go N, Monteiro C, Kleine-Schultjann J, Jemai S, Pham E, Boissel JP, Kulesza A. Arsène S, et al. Among authors: courcelles e. Methods Mol Biol. 2024;2716:51-99. doi: 10.1007/978-1-0716-3449-3_4. Methods Mol Biol. 2024. PMID: 37702936
Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility.
Musuamba FT, Skottheim Rusten I, Lesage R, Russo G, Bursi R, Emili L, Wangorsch G, Manolis E, Karlsson KE, Kulesza A, Courcelles E, Boissel JP, Rousseau CF, Voisin EM, Alessandrello R, Curado N, Dall'ara E, Rodriguez B, Pappalardo F, Geris L. Musuamba FT, et al. Among authors: courcelles e. CPT Pharmacometrics Syst Pharmacol. 2021 Aug;10(8):804-825. doi: 10.1002/psp4.12669. Epub 2021 Jul 13. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34102034 Free PMC article.
Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges.
Musuamba FT, Bursi R, Manolis E, Karlsson K, Kulesza A, Courcelles E, Boissel JP, Lesage R, Crozatier C, Voisin EM, Rousseau CF, Marchal T, Alessandrello R, Geris L. Musuamba FT, et al. Among authors: courcelles e. CPT Pharmacometrics Syst Pharmacol. 2020 Apr;9(4):195-197. doi: 10.1002/psp4.12504. Epub 2020 Apr 1. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32237207 Free PMC article. No abstract available.
Possible Contexts of Use for In Silico Trials Methodologies: A Consensus-Based Review.
Viceconti M, Emili L, Afshari P, Courcelles E, Curreli C, Famaey N, Geris L, Horner M, Jori MC, Kulesza A, Loewe A, Neidlin M, Reiterer M, Rousseau CF, Russo G, Sonntag SJ, Voisin EM, Pappalardo F. Viceconti M, et al. Among authors: courcelles e. IEEE J Biomed Health Inform. 2021 Oct;25(10):3977-3982. doi: 10.1109/JBHI.2021.3090469. Epub 2021 Oct 5. IEEE J Biomed Health Inform. 2021. PMID: 34161248 Free article. Review.
Credibility assessment of a mechanistic model of atherosclerosis to predict cardiovascular outcomes under lipid-lowering therapy.
Wang Y, Courcelles E, Peyronnet E, Porte S, Diatchenko A, Jacob E, Angoulvant D, Amarenco P, Boccara F, Cariou B, Mahé G, Steg PG, Bastien A, Portal L, Boissel JP, Granjeon-Noriot S, Bechet E. Wang Y, et al. Among authors: courcelles e. NPJ Digit Med. 2025 Mar 19;8(1):171. doi: 10.1038/s41746-025-01557-7. NPJ Digit Med. 2025. PMID: 40108310 Free PMC article.
In-silico trial emulation to predict the cardiovascular protection of new lipid-lowering drugs: an illustration through the design of the SIRIUS programme.
Angoulvant D, Granjeon-Noriot S, Amarenco P, Bastien A, Bechet E, Boccara F, Boissel JP, Cariou B, Courcelles E, Diatchenko A, Filipovics A, Kahoul R, Mahé G, Peyronnet E, Portal L, Porte S, Wang Y, Steg PG. Angoulvant D, et al. Among authors: courcelles e. Eur J Prev Cardiol. 2024 Nov 11;31(15):1820-1830. doi: 10.1093/eurjpc/zwae254. Eur J Prev Cardiol. 2024. PMID: 39101472