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Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways.
Yamaguchi M, Miyano K, Hirayama S, Karasawa Y, Ohshima K, Uezono E, Komatsu A, Nonaka M, Fujii H, Yamaguchi K, Iseki M, Hayashida M, Uezono Y. Yamaguchi M, et al. Among authors: uezono y, uezono e. Molecules. 2022 Oct 19;27(20):7065. doi: 10.3390/molecules27207065. Molecules. 2022. PMID: 36296658 Free PMC article.
Distinct Profiles of Desensitization of µ-Opioid Receptors Caused by Remifentanil or Fentanyl: In Vitro Assay with Cells and Three-Dimensional Structural Analyses.
Uezono E, Mizobuchi Y, Miyano K, Ohbuchi K, Murata H, Komatsu A, Manabe S, Nonaka M, Hirokawa T, Yamaguchi K, Iseki M, Uezono Y, Hayashida M, Kawagoe I. Uezono E, et al. Among authors: uezono y. Int J Mol Sci. 2023 May 6;24(9):8369. doi: 10.3390/ijms24098369. Int J Mol Sci. 2023. PMID: 37176075 Free PMC article.
Therapeutic Potential of Orally Administered Rubiscolin-6.
Karasawa Y, Miyano K, Yamaguchi M, Nonaka M, Yamaguchi K, Iseki M, Kawagoe I, Uezono Y. Karasawa Y, et al. Among authors: uezono y. Int J Mol Sci. 2023 Jun 9;24(12):9959. doi: 10.3390/ijms24129959. Int J Mol Sci. 2023. PMID: 37373107 Free PMC article. Review.
G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression.
Kajitani N, Okada-Tsuchioka M, Inoue A, Miyano K, Masuda T, Boku S, Iwamoto K, Ohtsuki S, Uezono Y, Aoki J, Takebayashi M. Kajitani N, et al. Among authors: uezono y. Neuropsychopharmacology. 2024 Feb;49(3):561-572. doi: 10.1038/s41386-023-01727-9. Epub 2023 Sep 6. Neuropsychopharmacology. 2024. PMID: 37673966 Free PMC article.
Structure-Activity Relationship Study of CYM51010, an agonist for the µ-δ Opioid Receptor Heterodimer.
Watanabe A, Yamada S, Yoshida H, Inagaki M, Atsumi N, Matsushima A, Takahashi N, Ishibashi N, Ogino T, Someya R, Taguchi A, Kagaya R, Ashizawa K, Mendori H, Karasawa Y, Ohshima K, Yokoyama A, Nonaka M, Miyano K, Karaki F, Hirayama S, Itoh K, Uezono Y, Fujii H. Watanabe A, et al. Among authors: uezono y. Chem Pharm Bull (Tokyo). 2024;72(7):711-730. doi: 10.1248/cpb.c24-00188. Chem Pharm Bull (Tokyo). 2024. PMID: 39085079 Free article.
256 results