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The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-Implications for the toxic gain of function observed in ALS.
Streltsov VA, Ganio KE, Nuttall SD, Hernandez JA, Dennys CN, Crouch PJ, Estevez AG, Franco MC, Beckman JS, Roberts BR. Streltsov VA, et al. Among authors: beckman js. bioRxiv [Preprint]. 2025 Sep 10:2025.09.10.675162. doi: 10.1101/2025.09.10.675162. bioRxiv. 2025. Update in: Neurobiol Dis. 2025 Dec;217:107189. doi: 10.1016/j.nbd.2025.107189. PMID: 40964393 Free PMC article. Updated. Preprint.
Integrated elemental analysis supports targeting copper perturbations as a therapeutic strategy in multiple sclerosis.
Hilton JBW, Kysenius K, Liddell JR, Mercer SW, Rautengarten C, Hare DJ, Buncic G, Paul B, Murray SS, McLean CA, Kilpatrick TJ, Beckman JS, Ayton S, Bush AI, White AR, Roberts BR, Donnelly PS, Crouch PJ. Hilton JBW, et al. Among authors: beckman js. Neurotherapeutics. 2024 Sep;21(5):e00432. doi: 10.1016/j.neurot.2024.e00432. Epub 2024 Aug 19. Neurotherapeutics. 2024. PMID: 39164165 Free PMC article.
Microglial ferroptotic stress causes non-cell autonomous neuronal death.
Liddell JR, Hilton JBW, Kysenius K, Billings JL, Nikseresht S, McInnes LE, Hare DJ, Paul B, Mercer SW, Belaidi AA, Ayton S, Roberts BR, Beckman JS, McLean CA, White AR, Donnelly PS, Bush AI, Crouch PJ. Liddell JR, et al. Among authors: beckman js. Mol Neurodegener. 2024 Feb 5;19(1):14. doi: 10.1186/s13024-023-00691-8. Mol Neurodegener. 2024. PMID: 38317225 Free PMC article.
PermaPhos Ser : autonomous synthesis of functional, permanently phosphorylated proteins.
Zhu P, Franklin R, Vogel A, Stanisheuski S, Reardon P, Sluchanko NN, Beckman JS, Karplus PA, Mehl RA, Cooley RB. Zhu P, et al. Among authors: beckman js. bioRxiv [Preprint]. 2021 Dec 14:2021.10.22.465468. doi: 10.1101/2021.10.22.465468. bioRxiv. 2021. Update in: ACS Cent Sci. 2023 Apr 10;9(4):816-835. doi: 10.1021/acscentsci.3c00191. PMID: 34931187 Free PMC article. Updated. Preprint.
198 results