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NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome.
Coombs JR, Zamoshnikova A, Holley CL, Maddugoda MP, Teo DET, Chauvin C, Poulin LF, Vitak N, Ross CM, Mellacheruvu M, Coll RC, Heinz LX, Burgener SS, Emming S, Chamaillard M, Boucher D, Schroder K. Coombs JR, et al. Sci Signal. 2024 Jan 23;17(820):eabg8145. doi: 10.1126/scisignal.abg8145. Epub 2024 Jan 23. Sci Signal. 2024. PMID: 38261657
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells.
Holley CL, Monteleone M, Fisch D, Libert AES, Ju RJ, Choi JH, Condon ND, Emming S, Crawford J, Lawrence GMEP, Coombs JR, Lefevre JG, Bajracharya R, Lahoud MH, Yap AS, Hamilton N, Stehbens SJ, Kagan JC, Ariotti N, Burgener SS, Schroder K. Holley CL, et al. Among authors: coombs jr. Nat Immunol. 2025 Jan;26(1):42-52. doi: 10.1038/s41590-024-02024-3. Epub 2024 Dec 4. Nat Immunol. 2025. PMID: 39633178 Free PMC article.
Spectosis: Dying for a complement.
Coombs JR, Burgener SS, Schroder K. Coombs JR, et al. Immunity. 2025 Jun 10;58(6):1372-1374. doi: 10.1016/j.immuni.2025.05.017. Immunity. 2025. PMID: 40499516
Pd-Catalyzed Chemoselective O‑Benzylation of Ambident 2‑Quinolinone Nucleophiles.
Cadena M, Villatoro RS, Gupta JS, Phillips C, Allen JB, Arman HD, Wherritt DJ, Clanton NA, Ruchelman AL, Simmons EM, DelMonte AJ, Coombs JR, Frantz DE. Cadena M, et al. Among authors: coombs jr. ACS Catal. 2022 Aug 19;12(16):10199-10206. doi: 10.1021/acscatal.2c02783. Epub 2022 Aug 5. ACS Catal. 2022. PMID: 40852209 Free PMC article.
19 results