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Page 1
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk.
Zhang X, Kapoor D, Jeong SJ, Fappi A, Stitham J, Shabrish V, Sergin I, Yousif E, Rodriguez-Velez A, Yeh YS, Park A, Yurdagul A Jr, Rom O, Epelman S, Schilling JD, Sardiello M, Diwan A, Cho J, Stitziel NO, Javaheri A, Lodhi IJ, Mittendorfer B, Razani B. Zhang X, et al. Among authors: javaheri a. Nat Metab. 2024 Feb;6(2):359-377. doi: 10.1038/s42255-024-00984-2. Epub 2024 Feb 19. Nat Metab. 2024. PMID: 38409323 Free PMC article.
Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor-Biased Ligand in Adults With COVID-19: Two Randomized Clinical Trials.
Self WH, Shotwell MS, Gibbs KW, de Wit M, Files DC, Harkins M, Hudock KM, Merck LH, Moskowitz A, Apodaca KD, Barksdale A, Safdar B, Javaheri A, Sturek JM, Schrager H, Iovine N, Tiffany B, Douglas IS, Levitt J, Busse LW, Ginde AA, Brown SM, Hager DN, Boyle K, Duggal A, Khan A, Lanspa M, Chen P, Puskarich M, Vonderhaar D, Venkateshaiah L, Gentile N, Rosenberg Y, Troendle J, Bistran-Hall AJ, DeClercq J, Lavieri R, Joly MM, Orr M, Pulley J, Rice TW, Schildcrout JS, Semler MW, Wang L, Bernard GR, Collins SP; ACTIV-4 Host Tissue Investigators. Self WH, et al. Among authors: javaheri a. JAMA. 2023 Apr 11;329(14):1170-1182. doi: 10.1001/jama.2023.3546. JAMA. 2023. PMID: 37039791 Free PMC article.
JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit.
Guo Z, Hu YH, Feng GS, Valenzuela Ripoll C, Li ZZ, Cai SD, Wang QQ, Luo WW, Li Q, Liang LY, Wu ZK, Zhang JG, Javaheri A, Wang L, Lu J, Liu PQ. Guo Z, et al. Among authors: javaheri a. Acta Pharmacol Sin. 2023 Sep;44(9):1777-1789. doi: 10.1038/s41401-023-01086-7. Epub 2023 Apr 25. Acta Pharmacol Sin. 2023. PMID: 37186122 Free PMC article.
Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia: A Randomized Clinical Trial.
Collins SP, Shotwell MS, Strich JR, Gibbs KW, de Wit M, Files DC, Harkins M, Hudock K, Merck LH, Moskowitz A, Apodaca KD, Barksdale A, Safdar B, Javaheri A, Sturek JM, Schrager H, Iovine NM, Tiffany B, Douglas I, Levitt J, Ginde AA, Hager DN, Shapiro N, Duggal A, Khan A, Lanspa M, Chen P, Gentile N, Harris E, Gong M, Sellers S, Goodwin AJ, Tidswell MA, Filbin M, Desai N, Gutiérrez F, Estrada V, Burgos J, Boyles T, Paño-Pardo JR, Hussen N, Rosenberg Y, Troendle J, Bernard GR, Bistran-Hall AJ, Walsh K, Casey JD, DeClercq J, Joly MM, Pulley J, Rice TW, Schildcrout JS, Wang L, Semler MW, Self WH; ACTIV-4 Host Tissue Investigators. Collins SP, et al. Among authors: javaheri a. JAMA Netw Open. 2024 Dec 2;7(12):e2448215. doi: 10.1001/jamanetworkopen.2024.48215. JAMA Netw Open. 2024. PMID: 39625722 Free PMC article. Clinical Trial.
Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity.
Ozcan M, Guo Z, Valenzuela Ripoll C, Diab A, Picataggi A, Rawnsley D, Lotfinaghsh A, Bergom C, Szymanski J, Hwang D, Asnani A, Kosiborod M, Zheng J, Hayashi RJ, Woodard PK, Kovacs A, Margulies KB, Schilling J, Razani B, Diwan A, Javaheri A. Ozcan M, et al. Among authors: javaheri a. Cell Metab. 2023 Jun 6;35(6):928-942.e4. doi: 10.1016/j.cmet.2023.02.006. Epub 2023 Mar 2. Cell Metab. 2023. PMID: 36868222 Free PMC article. Clinical Trial.
Ketones with a twist: Tipping the heart's hat to fat.
Javaheri A, Mittendorfer B. Javaheri A, et al. Obesity (Silver Spring). 2024 Mar;32(3):452-453. doi: 10.1002/oby.23990. Epub 2024 Jan 29. Obesity (Silver Spring). 2024. PMID: 38287645 Free PMC article. No abstract available.
Identification of lysosomal lipolysis as an essential noncanonical mediator of adipocyte fasting and cold-induced lipolysis.
Yeh YS, Evans TD, Iwase M, Jeong SJ, Zhang X, Liu Z, Park A, Ghasemian A, Dianati B, Javaheri A, Kratky D, Kawarasaki S, Goto T, Zhang H, Dutta P, Schopfer FJ, Straub AC, Cho J, Lodhi IJ, Razani B. Yeh YS, et al. Among authors: javaheri a. J Clin Invest. 2025 Mar 17;135(6):e185340. doi: 10.1172/JCI185340. J Clin Invest. 2025. PMID: 40091840 Free PMC article.
157 results