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Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease.
D'Alessandro A, Le K, Lundt M, Li Q, Dunkelberger EB, Cellmer T, Worth AJ, Patil S, Huston C, Grier A, Dzieciatkowska M, Stephenson D, Eaton WA, Thein SL. D'Alessandro A, et al. Among authors: le k. Haematologica. 2024 Aug 1;109(8):2639-2652. doi: 10.3324/haematol.2023.284831. Haematologica. 2024. PMID: 38450513 Free PMC article. Clinical Trial.
NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers.
Jeong J, Hausmann S, Dong H, Szczepski K, Flores NM, Garcia Gonzalez A, Shi L, Lu X, Lempiäinen J, Jakab M, Zeng L, Chasan T, Bareke E, Dong R, Carlson E, Padilla R, Husmann D, Thompson J, Shipman GA, Zahn E, Barnes CA, Khan LF, Albertorio-Sáez LM, Brill E, Kumary VUS, Marunde MR, Maryanski DN, Szany CC, Venters BJ, Windham CL, Nowakowski ME, Czaban I, Jaremko M, Keogh MC, Le K, Soth MJ, Garcia BA, Jaremko Ł, Majewski J, Mazur PK, Gozani O. Jeong J, et al. Among authors: le k. Nature. 2025 Aug 6. doi: 10.1038/s41586-025-09299-y. Online ahead of print. Nature. 2025. PMID: 40770093
1,063 results