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Page 1
Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms.
Lambourne L, Mattioli K, Santoso C, Sheynkman G, Inukai S, Kaundal B, Berenson A, Spirohn-Fitzgerald K, Bhattacharjee A, Rothman E, Shrestha S, Laval F, Carroll BS, Plassmeyer SP, Emenecker RJ, Yang Z, Bisht D, Sewell JA, Li G, Prasad A, Phanor S, Lane R, Moyer DC, Hunt T, Balcha D, Gebbia M, Twizere JC, Hao T, Holehouse AS, Frankish A, Riback JA, Salomonis N, Calderwood MA, Hill DE, Sahni N, Vidal M, Bulyk ML, Fuxman Bass JI. Lambourne L, et al. Among authors: plassmeyer sp. Mol Cell. 2025 Apr 3;85(7):1445-1466.e13. doi: 10.1016/j.molcel.2025.03.004. Epub 2025 Mar 26. Mol Cell. 2025. PMID: 40147441
Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain.
Shepherdson JL, Granas DM, Li J, Shariff Z, Plassmeyer SP, Holehouse AS, White MA, Cohen BA. Shepherdson JL, et al. Among authors: plassmeyer sp. bioRxiv [Preprint]. 2024 Mar 27:2024.03.21.585809. doi: 10.1101/2024.03.21.585809. bioRxiv. 2024. Update in: Genome Res. 2024 Oct 29;34(10):1540-1552. doi: 10.1101/gr.279415.124. PMID: 38585983 Free PMC article. Updated. Preprint.
A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of non-coding elements in vivo.
Lagunas T Jr, Plassmeyer SP, Fischer AD, Friedman RZ, Rieger MA, Selmanovic D, Sarafinovska S, Sol YK, Kasper MJ, Fass SB, Aguilar Lucero AF, An JY, Sanders SJ, Cohen BA, Dougherty JD. Lagunas T Jr, et al. Among authors: plassmeyer sp. Commun Biol. 2023 Nov 13;6(1):1151. doi: 10.1038/s42003-023-05483-w. Commun Biol. 2023. PMID: 37953348 Free PMC article.