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The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation.
Totland MZ, Knudsen LM, Rasmussen NL, Omori Y, Sørensen V, Elster VCW, Stenersen JM, Larsen M, Jensen CL, Zickfeldt Lade AA, Bruusgaard E, Basing S, Kryeziu K, Brech A, Aasen T, Lothe RA, Leithe E. Totland MZ, et al. Among authors: leithe e. Cell Mol Life Sci. 2024 Apr 10;81(1):171. doi: 10.1007/s00018-024-05165-8. Cell Mol Life Sci. 2024. PMID: 38597989 Free PMC article.
Endocytic trafficking of connexins in cancer pathogenesis.
Totland MZ, Omori Y, Sørensen V, Kryeziu K, Aasen T, Brech A, Leithe E. Totland MZ, et al. Among authors: leithe e. Biochim Biophys Acta Mol Basis Dis. 2023 Oct;1869(7):166812. doi: 10.1016/j.bbadis.2023.166812. Epub 2023 Jul 16. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 37454772 Free article. Review.
Downregulation of gap junctions in cancer cells.
Leithe E, Sirnes S, Omori Y, Rivedal E. Leithe E, et al. Crit Rev Oncog. 2006 Dec;12(3-4):225-56. doi: 10.1615/critrevoncog.v12.i3-4.30. Crit Rev Oncog. 2006. PMID: 17425504 Review.
The connexin 43 C-terminus: A tail of many tales.
Leithe E, Mesnil M, Aasen T. Leithe E, et al. Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):48-64. doi: 10.1016/j.bbamem.2017.05.008. Epub 2017 May 16. Biochim Biophys Acta Biomembr. 2018. PMID: 28526583 Free article. Review.
38 results