The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Polθ ATPase Inhibitor.
Mochirian P, Papp R, Mathieu MC, Ferraro GB, Dietrich E, Liu B, Bendahan D, Perryman AL, Surprenant S, Fournier S, Barzili BL, Bonneau-Fortin A, Yin SY, Leclaire ME, Patel C, Poirier H, Save S, Mathieu Y, Morin N, Godbout C, Burston HE, Zahn KE, Attia MA, Pinter T, Barabé F, Parikh P, Jagani C, Kang G, Scapin G, Mamane Y, Sfeir A, Mader P, Sicheri F, Zimmermann M, Roulston A, Morris SJ, Black WC, Gallant M.
Mochirian P, et al. Among authors: mathieu mc.
J Med Chem. 2025 Sep 25;68(18):19726-19745. doi: 10.1021/acs.jmedchem.5c02103. Epub 2025 Sep 8.
J Med Chem. 2025.
PMID: 40920169