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328 results

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Page 1
Structural and molecular basis of choline uptake into the brain by FLVCR2.
Cater RJ, Mukherjee D, Gil-Iturbe E, Erramilli SK, Chen T, Koo K, Santander N, Reckers A, Kloss B, Gawda T, Choy BC, Zhang Z, Katewa A, Larpthaveesarp A, Huang EJ, Mooney SWJ, Clarke OB, Yee SW, Giacomini KM, Kossiakoff AA, Quick M, Arnold T, Mancia F. Cater RJ, et al. Among authors: quick m. Nature. 2024 May;629(8012):704-709. doi: 10.1038/s41586-024-07326-y. Epub 2024 May 1. Nature. 2024. PMID: 38693257 Free PMC article.
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
Mok S, Yeo T, Hong D, Shears MJ, Ross LS, Ward KE, Dhingra SK, Kanai M, Bridgford JL, Tripathi AK, Mlambo G, Burkhard AY, Fairhurst KJ, Gil-Iturbe E, Park H, Rozenberg FD, Kim J, Mancia F, Quick M, Uhlemann AC, Sinnis P, Fidock DA. Mok S, et al. Among authors: quick m. bioRxiv [Preprint]. 2023 Jun 3:2023.06.02.543338. doi: 10.1101/2023.06.02.543338. bioRxiv. 2023. Update in: Sci Adv. 2023 Nov 10;9(45):eadi2364. doi: 10.1126/sciadv.adi2364. PMID: 37398288 Free PMC article. Updated. Preprint.
Effects of the Quinone Analog Ubiquinone-5 on Murine Mitochondria and Hypnosis.
Somnay YR, Wang A, Lim H, Griffiths KK, Zandkarimi F, Chen K, Yang G, Wasilczuk AZ, Kelz MB, Larr D, Yang M, Gil-Iturbe E, Moon A, Quick M, Levy RJ. Somnay YR, et al. Among authors: quick m. Anesthesiology. 2025 Sep 1;143(3):641-660. doi: 10.1097/ALN.0000000000005549. Epub 2025 May 2. Anesthesiology. 2025. PMID: 40315373
A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants.
Ferreira LT, Cassiano GC, Alvarez LCS, Okombo J, Calit J, Fontinha D, Gil-Iturbe E, Coyle R, Andrade CH, Sunnerhagen P, Bargieri DY, Prudêncio M, Quick M, Cravo PV, Lee MCS, Fidock DA, Costa FTM. Ferreira LT, et al. Among authors: quick m. PLoS Pathog. 2024 Oct 29;20(10):e1012627. doi: 10.1371/journal.ppat.1012627. eCollection 2024 Oct. PLoS Pathog. 2024. PMID: 39471233 Free PMC article.
Plasmodium falciparum quinine resistance is multifactorial and includes a role for the drug/metabolite transporters PfCRT and DMT1.
Kanai M, Mok S, Yeo T, Shears MJ, Jeon JH, Narwal SK, Ross LS, Haile MT, Tripathi AK, Mlambo G, Kim J, Gil-Iturbe E, Okombo J, Park H, Wiradiputri K, Ward KE, Rozenberg FD, Fairhurst KJ, Bloxham TS, Bridgford JL, Sheth TR, Lee MCS, Small-Saunders JL, Mancia F, Quick M, Uhlemann AC, Sinnis P, Fidock DA. Kanai M, et al. Among authors: quick m. bioRxiv [Preprint]. 2025 Apr 11:2024.09.27.615529. doi: 10.1101/2024.09.27.615529. bioRxiv. 2025. PMID: 39386571 Free PMC article. Preprint.
Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration.
Buck SA, Rubin SA, Kunkhyen T, Treiber CD, Xue X, Fenno LE, Mabry SJ, Sundar VR, Yang Z, Shah D, Ketchesin KD, Becker-Krail DD, Vasylieva I, Smith MC, Weisel FJ, Wang W, Erickson-Oberg MQ, O'Leary EI, Aravind E, Ramakrishnan C, Kim YS, Wu Y, Quick M, Coleman JA, MacDonald WA, Elbakri R, Olsen AL, Rocha EM, Miller GW, De Miranda BR, Palladino MJ, McCabe BD, Fish KN, Seney ML, Rayport S, Mingote S, Deisseroth K, Hnasko TS, Awatramani R, Watson AM, Waddell S, Cheetham CEJ, Logan RW, Freyberg Z. Buck SA, et al. Among authors: quick m. bioRxiv [Preprint]. 2025 Jul 10:2023.10.02.560584. doi: 10.1101/2023.10.02.560584. bioRxiv. 2025. PMID: 37873436 Free PMC article. Preprint.
Mechanistic snapshots of lipid-linked sugar transfer.
Morgan RT, Motta S, Gil-Iturbe E, Bhattacharjee B, Anwar MT, Di Muccio G, Romagnoli A, Mishra B, Ashraf KU, Bang I, Di Marino D, Lowary TL, Quick M, Petrou VI, Stowell MHB, Nygaard R, Mancia F. Morgan RT, et al. Among authors: quick m. Nat Commun. 2025 Dec 6;16(1):11044. doi: 10.1038/s41467-025-66769-7. Nat Commun. 2025. PMID: 41353435 Free PMC article.
Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance.
Okombo J, Ndiaye T, Qahash T, Moura IMR, Gil-Iturbe E, Hagenah LM, Bridgford JL, Bonatto V, Ward KE, Yeo T, Narwal SK, Orta LV, Anderson I, Dhingra SK, Pasaje CFA, Park H, Kim J, Guido RVC, Angulo-Barturen I, Niles JC, Mancia F, Uhlemann AC, Mok S, Quick M, Winzeler EA, Leroy D, Llinás M, Thathy V, Fidock DA. Okombo J, et al. Among authors: quick m. Res Sq [Preprint]. 2025 Oct 9:rs.3.rs-7697517. doi: 10.21203/rs.3.rs-7697517/v1. Res Sq. 2025. PMID: 41282051 Free PMC article. Preprint.
328 results