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Page 1
Distinct mechanisms of non-autonomous UPRER mediated by GABAergic, glutamatergic, and octopaminergic neurons.
Coakley AJ, Hruby AJ, Wang J, Bong A, Nair T, Ramos CM, Alcala A, Hicks D, Averbukh M, Dutta N, Moaddeli D, Siebrand C, Rogers MLR, Sahay A, Curran SP, Mullen PJ, Benayoun BA, Garcia G, Higuchi-Sanabria R. Coakley AJ, et al. Among authors: hruby aj. bioRxiv [Preprint]. 2024 Dec 24:2024.05.27.595950. doi: 10.1101/2024.05.27.595950. bioRxiv. 2024. Update in: Commun Biol. 2025 Nov 24;8(1):1650. doi: 10.1038/s42003-025-09036-1. PMID: 38854121 Free PMC article. Updated. Preprint.
Glial-derived mitochondrial signals impact neuronal proteostasis and aging.
Bar-Ziv R, Dutta N, Hruby A, Sukarto E, Averbukh M, Alcala A, Henderson HR, Durieux J, Tronnes SU, Ahmad Q, Bolas T, Perez J, Dishart JG, Vega M, Garcia G, Higuchi-Sanabria R, Dillin A. Bar-Ziv R, et al. bioRxiv [Preprint]. 2023 Aug 8:2023.07.20.549924. doi: 10.1101/2023.07.20.549924. bioRxiv. 2023. Update in: Sci Adv. 2023 Oct 13;9(41):eadi1411. doi: 10.1126/sciadv.adi1411. PMID: 37609253 Free PMC article. Updated. Preprint.
Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging.
Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Castro Torres T, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. Dutta N, et al. bioRxiv [Preprint]. 2023 Nov 27:2023.11.27.568896. doi: 10.1101/2023.11.27.568896. bioRxiv. 2023. PMID: 38077060 Free PMC article. Preprint.
Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging.
Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Kim J, Torres TC, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. Dutta N, et al. Geroscience. 2024 Dec;46(6):6009-6028. doi: 10.1007/s11357-024-01144-w. Epub 2024 Apr 3. Geroscience. 2024. PMID: 38570396 Free PMC article.
Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans.
Oorloff M, Hruby A, Averbukh M, Alcala A, Dutta N, Torres TC, Moaddeli D, Vega M, Kim J, Bong A, Coakley AJ, Hicks D, Wang J, Wang T, Hoang S, Tharp KM, Garcia G, Higuchi-Sanabria R. Oorloff M, et al. Among authors: hruby a. bioRxiv [Preprint]. 2024 Apr 12:2024.04.11.589121. doi: 10.1101/2024.04.11.589121. bioRxiv. 2024. Update in: PLoS One. 2024 Sep 12;19(9):e0302673. doi: 10.1371/journal.pone.0302673. PMID: 38645203 Free PMC article. Updated. Preprint.
Growth on stiffer substrates impacts animal health and longevity in C. elegans.
Oorloff M, Hruby A, Averbukh M, Alcala A, Dutta N, Minor C, Castro Torres T, Moaddeli D, Vega M, Kim J, Bong A, Coakley AJ, Hicks D, Wang J, Wang T, Hoang S, Tharp KM, Garcia G, Higuchi-Sanabria R. Oorloff M, et al. Among authors: hruby a. PLoS One. 2024 Sep 12;19(9):e0302673. doi: 10.1371/journal.pone.0302673. eCollection 2024. PLoS One. 2024. PMID: 39264947 Free PMC article.
Distinct responses to non-autonomous UPRER mediated by glutamatergic and octopaminergic neurons.
Coakley AJ, Hruby AJ, Wang J, Bong A, Nair T, Ramos CM, Alcala A, Hicks D, Averbukh M, Dutta N, Moaddeli D, Pearson C, Siebrand CJ, de Los Rios Rogers M, Sahay A, Curran SP, Mullen PJ, Benayoun BA, Garcia G, Higuchi-Sanabria R. Coakley AJ, et al. Among authors: hruby aj. Commun Biol. 2025 Nov 24;8(1):1650. doi: 10.1038/s42003-025-09036-1. Commun Biol. 2025. PMID: 41286443 Free PMC article.
Characterization of cellular senescence in aging skeletal muscle.
Zhang X, Habiballa L, Aversa Z, Ng YE, Sakamoto AE, Englund DA, Pearsall VM, White TA, Robinson MM, Rivas DA, Dasari S, Hruby AJ, Lagnado AB, Jachim SK, Granic A, Sayer AA, Jurk D, Lanza IR, Khosla S, Fielding RA, Nair KS, Schafer MJ, Passos JF, LeBrasseur NK. Zhang X, et al. Among authors: hruby aj. Nat Aging. 2022 Jul;2(7):601-615. doi: 10.1038/s43587-022-00250-8. Epub 2022 Jul 15. Nat Aging. 2022. PMID: 36147777 Free PMC article.