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Page 1
Addition of oncolytic virotherapy to clinical isolated limb perfusion for melanoma and sarcoma activates antitumor immunity.
Hayes AJ, Davies EJ, Wilkinson M, Smith HG, Nenclares P, Lund T, Larkeryd A, Appleton E, Patin EC, Pedersen M, Rullan A, Mohamed HS, Aronson L, Murphy J, Grove L, Mansfield D, Mclaughlin M, Harrington KJ, Melcher A. Hayes AJ, et al. Among authors: appleton e. J Immunother Cancer. 2025 Sep 26;13(9):e012446. doi: 10.1136/jitc-2025-012446. J Immunother Cancer. 2025. PMID: 41005981 Free PMC article. Clinical Trial.
Author Correction: Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion.
Roulstone V, Kyula-Currie J, Wright J, Patin EC, Dean I, Yu L, Barreiro-Alonso A, Melake M, Choudhary J, Elliott R, Lord CJ, Mansfield D, Matthews N, Chauhan R, Jennings V, Chan Wah Hak C, Baldock H, Butera F, Appleton E, Nenclares P, Pedersen M, Foo S, Wongariyapak A, Rullan A, Tenev T, Meier P, Vile R, Pandha H, Melcher A, McLaughlin M, Harrington KJ. Roulstone V, et al. Among authors: appleton e. Nat Commun. 2025 Jul 15;16(1):6510. doi: 10.1038/s41467-025-61212-3. Nat Commun. 2025. PMID: 40664654 Free PMC article. No abstract available.
The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models.
Kyula-Currie J, Roulstone V, Wright J, Butera F, Legrand A, Elliott R, McLaughlin M, Bozhanova G, Krastev D, Pettitt S, Tenev T, Dillon M, Foo S, Patin EC, Jennings V, Chan Wah Hak C, Appleton E, Wongariyapak A, Pedersen M, Rullan A, Choudhary J, Bakal C, Meier P, Lord CJ, Melcher A, Harrington KJ. Kyula-Currie J, et al. Among authors: appleton e. Nat Commun. 2025 Jul 8;16(1):6299. doi: 10.1038/s41467-025-61297-w. Nat Commun. 2025. PMID: 40628717 Free PMC article.
RP1 Combined With Nivolumab in Advanced Anti-PD-1-Failed Melanoma (IGNYTE).
Wong MK, Milhem MM, Sacco JJ, Michels J, In GK, Muñoz Couselo E, Schadendorf D, Beasley GM, Niu J, Chmielowski B, Wise-Draper TM, Bowles TL, Tsai KK, Lebbé C, Gaudy-Marqueste C, Middleton MR, Skolariki A, Samson A, Chesney JA, VanderWalde AM, Zakharia Y, Harrington KJ, Appleton E, Bommareddy PK, Zhu J, Viana M, Hou JW, Coffin RS, Robert C. Wong MK, et al. Among authors: appleton e. J Clin Oncol. 2025 Jul 8:JCO2501346. doi: 10.1200/JCO-25-01346. Online ahead of print. J Clin Oncol. 2025. PMID: 40627813
Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC.
Liu S, Li L, Zhang F, Garcia-Corral M, Meyer K, Fortuna PRJ, van Sambeek B, Appleton E, Ng AHM, Khoshakhlagh P, Lu YR, Cameron J, Ramirez RN, Chen Y, Wu CT, Huang JY, Tan Y, Chao G, Aach J, Lim ET, Tam JM, Raychaudhuri S, Church GM. Liu S, et al. Among authors: appleton e. Nat Commun. 2025 Jun 10;16(1):5136. doi: 10.1038/s41467-025-59596-3. Nat Commun. 2025. PMID: 40494892 Free PMC article.
Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion.
Roulstone V, Kyula-Currie J, Wright J, Patin EC, Dean I, Yu L, Barreiro-Alonso A, Melake M, Choudhary J, Elliott R, Lord CJ, Mansfield D, Matthews N, Chauhan R, Jennings V, Chan Wah Hak C, Baldock H, Butera F, Appleton E, Nenclares P, Pedersen M, Foo S, Wongariyapak A, Rullan A, Tenev T, Meier P, Vile R, Pandha H, Melcher A, McLaughlin M, Harrington KJ. Roulstone V, et al. Among authors: appleton e. Nat Commun. 2025 May 25;16(1):4855. doi: 10.1038/s41467-025-60133-5. Nat Commun. 2025. PMID: 40413207 Free PMC article.
53 results