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Page 1
Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML.
DeRatt LG, Zhang Z, Pietsch C, Cisar JS, Zhang X, Wang W, Tanner A, Matico R, Shaffer P, Jacoby E, Kazmi F, Shukla N, Bush TL, Patrick A, Philippar U, Attar R, Edwards JP, Kuduk SD. DeRatt LG, et al. Among authors: cisar js. J Med Chem. 2024 Jul 11;67(13):11254-11272. doi: 10.1021/acs.jmedchem.4c00809. Epub 2024 Jun 18. J Med Chem. 2024. PMID: 38889244
Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators.
Clapper JR, Henry CL, Niphakis MJ, Knize AM, Coppola AR, Simon GM, Ngo N, Herbst RA, Herbst DM, Reed AW, Cisar JS, Weber OD, Viader A, Alexander JP, Cunningham ML, Jones TK, Fraser IP, Grice CA, Ezekowitz RAB, O'Neill GP, Blankman JL. Clapper JR, et al. Among authors: cisar js. J Pharmacol Exp Ther. 2018 Dec;367(3):494-508. doi: 10.1124/jpet.118.252296. Epub 2018 Oct 10. J Pharmacol Exp Ther. 2018. PMID: 30305428 Free article.
Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis.
Struble TJ, Alvarez JC, Brown SP, Chytil M, Cisar J, DesJarlais RL, Engkvist O, Frank SA, Greve DR, Griffin DJ, Hou X, Johannes JW, Kreatsoulas C, Lahue B, Mathea M, Mogk G, Nicolaou CA, Palmer AD, Price DJ, Robinson RI, Salentin S, Xing L, Jaakkola T, Green WH, Barzilay R, Coley CW, Jensen KF. Struble TJ, et al. J Med Chem. 2020 Aug 27;63(16):8667-8682. doi: 10.1021/acs.jmedchem.9b02120. Epub 2020 Apr 14. J Med Chem. 2020. PMID: 32243158 Free PMC article.
Identification of isoquinolinone DHODH inhibitor isosteres.
DeRatt LG, Zhang Z, Pietsch EC, Cisar J, Wang A, Wang CY, Tanner A, Shaffer P, Jacoby E, Kazmi F, Shukla N, Philippar U, Attar RM, Edwards JP, Kuduk SD. DeRatt LG, et al. Bioorg Med Chem Lett. 2024 Nov 15;113:129965. doi: 10.1016/j.bmcl.2024.129965. Epub 2024 Sep 14. Bioorg Med Chem Lett. 2024. PMID: 39284456
Toward Dose Prediction at Point of Design.
Van Rompaey D, Ray Chaudhuri S, Ahmad M, Cisar J, Van Den Bergh A, Ash J, Wu Z, Bryan MC, Edwards JP, DesJarlais R, Wegner JK, Ceulemans H, Mitra K, Polidori D. Van Rompaey D, et al. J Med Chem. 2024 Dec 26;67(24):22282-22290. doi: 10.1021/acs.jmedchem.4c02385. Epub 2024 Dec 12. J Med Chem. 2024. PMID: 39666573
18 results