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Functional precision approach in patients with very high risk acute lymphoblastic leukaemia in India: a single-centre cohort study.
Sidhu J, Chakraborty A, Das P, Steffen FD, Kundu S, Basu S, Tarafdar B, Dey T, Kar A, Biswas M, Das A, Sivadasan N, Dasgupta P, Ghara N, Bornhauser B, Bourquin JP, Krishnan S, Saha V. Sidhu J, et al. Among authors: bornhauser b. Lancet Reg Health Southeast Asia. 2026 Jan 2;44:100710. doi: 10.1016/j.lansea.2025.100710. eCollection 2026 Jan. Lancet Reg Health Southeast Asia. 2026. PMID: 41551378 Free PMC article.
A clinical-stage oncology compound selectively targets drug-resistant cancers.
Long K, Bhattacharjee D, Newman-Stonebraker SH, Suhr S, Mercado BQ, Tighe A, Romero L, Thompson SL, Sausville EL, John KM, Julian L, Mishra S, Klingbeil O, Gupta P, Bhatt U, Gao AC, Ricardo S, Vakoc CR, Bornhauser BC, Corsello SM, Taylor SS, Holland PL, Sheltzer JM. Long K, et al. Among authors: bornhauser bc. bioRxiv [Preprint]. 2025 Nov 30:2025.11.26.690878. doi: 10.1101/2025.11.26.690878. bioRxiv. 2025. PMID: 41394735 Free PMC article. Preprint.
Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12.
Troester S, Eder T, Wukowits N, Piontek M, Fernández-Pernas P, Schmoellerl J, Haladik B, Manhart G, Allram M, Maurer-Granofszky M, Scheidegger N, Nebral K, Superti-Furga G, Meisel R, Bornhauser B, Valent P, Dworzak MN, Zuber J, Boztug K, Grebien F. Troester S, et al. Among authors: bornhauser b. Nat Commun. 2025 May 19;16(1):4656. doi: 10.1038/s41467-025-59930-9. Nat Commun. 2025. PMID: 40389480 Free PMC article.
SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response.
Ibrahim NK, Schreek S, Cinar B, Stasche AS, Lee SH, Zeug A, Dolgner T, Niessen J, Ponimaskin E, Shcherbata H, Fehlhaber B, Bourquin JP, Bornhauser B, Stanulla M, Pich A, Gutierrez A, Hinze L. Ibrahim NK, et al. Among authors: bornhauser b. Cell Rep. 2025 Apr 22;44(4):115434. doi: 10.1016/j.celrep.2025.115434. Epub 2025 Mar 24. Cell Rep. 2025. PMID: 40131931 Free PMC article.
IAP dependency of T-cell prolymphocytic leukemia identified by high-throughput drug screening.
Pohly MF, Putzker K, Scheinost S, Ben Taarit L, Walther T, Kummer S, Wertheimer T, Lin M, Do THL, Handler K, Michler J, Kivioja J, Bach K, Kisele S, Kim J, Dietrich S, Bornhauser B, Wong WW, Becher B, Moor A, Lewis J, Ficht X, Lu J, Huber W, Zenz T. Pohly MF, et al. Among authors: bornhauser b. Blood. 2025 May 15;145(20):2336-2352. doi: 10.1182/blood.2024027171. Blood. 2025. PMID: 39869826
Caspase-2 kills cells with extra centrosomes.
Rizzotto D, Vigorito V, Rieder P, Gallob F, Moretta GM, Soratroi C, Riley JS, Bellutti F, Veli SL, Mattivi A, Lohmüller M, Herzog S, Bornhauser BC, Jacotot ED, Villunger A, Fava LL. Rizzotto D, et al. Among authors: bornhauser bc. Sci Adv. 2024 Nov;10(44):eado6607. doi: 10.1126/sciadv.ado6607. Epub 2024 Oct 30. Sci Adv. 2024. PMID: 39475598 Free PMC article.
A first-in-class Wiskott-Aldrich syndrome protein activator with antitumor activity in hematologic cancers.
Spriano F, Sartori G, Sgrignani J, Barnabei L, Arribas AJ, Guala M, Del Amor AMC, Tomasso MR, Tarantelli C, Cascione L, Golino G, Riveiro ME, Bortolozzi R, Lupia A, Paduano F, Huguet S, Rezai K, Rinaldi A, Margheriti F, Ventura P, Guarda G, Costa G, Rocca R, Furlan A, Verdonk LM, Innocenti P, Martin NI, Viola G, Driessen C, Zucca E, Stathis A, Gahtory D, Van den Nieuwboer M, Bornhauser B, Alcaro S, Trapasso F, Cristobal S, Padrick SB, Pazzi N, Cavalli F, Cavalli A, Gaudio E, Bertoni F. Spriano F, et al. Among authors: bornhauser b. Haematologica. 2024 Nov 1;109(11):3602-3614. doi: 10.3324/haematol.2022.282672. Haematologica. 2024. PMID: 38899342 Free PMC article.
94 results