Varghese A - Search Results

1

Novel Insights into the Catalytic Mechanism of Collagenolysis by Zn(II)-Dependent Matrix Metalloproteinase-1.

Gorantla KR, Krishnan A, Waheed SO, Varghese A, DiCastri I, LaRouche C, Paik M, Fields GB, Karabencheva-Christova TG. Gorantla KR, et al. Among authors: varghese a. Biochemistry. 2024 Aug 6;63(15):1925-1940. doi: 10.1021/acs.biochem.4c00076. Epub 2024 Jul 4. Biochemistry. 2024. PMID: 38963231 Free PMC article.

2

A synergy between the catalytic and structural Zn(II) ions and the enzyme and substrate dynamics underlies the structure-function relationships of matrix metalloproteinase collagenolysis.

Varghese A, Chaturvedi SS, Fields GB, Karabencheva-Christova TG. Varghese A, et al. J Biol Inorg Chem. 2021 Aug;26(5):583-597. doi: 10.1007/s00775-021-01876-6. Epub 2021 Jul 6. J Biol Inorg Chem. 2021. PMID: 34228191 Free PMC article.

3

Effects of the Nature of the Metal Ion, Protein and Substrate on the Catalytic Center in Matrix Metalloproteinase-1: Insights from Multilevel MD, QM/MM and QM Studies.

Varghese A, Chaturvedi SS, DiCastri B, Mehler E, Fields GB, Karabencheva-Christova TG. Varghese A, et al. Chemphyschem. 2021 Dec 27;23(4):10.1002/cphc.202100680. doi: 10.1002/cphc.202100680. Chemphyschem. 2021. PMID: 35991515 Free PMC article.

4

Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase-1.

Waheed SO, Varghese A, DiCastri I, Kaski B, LaRouche C, Fields GB, Karabencheva-Christova TG. Waheed SO, et al. Among authors: varghese a. Chemphyschem. 2023 Feb 1;24(3):e202200649. doi: 10.1002/cphc.202200649. Epub 2022 Oct 25. Chemphyschem. 2023. PMID: 36161746

5

How Human TET2 Enzyme Catalyzes the Oxidation of Unnatural Cytosine Modifications in Double-Stranded DNA.

Waheed SO, Varghese A, Chaturvedi SS, Karabencheva-Christova TG, Christov CZ. Waheed SO, et al. Among authors: varghese a. ACS Catal. 2022 May 6;12(9):5327-5344. doi: 10.1021/acscatal.2c00024. Epub 2022 Apr 19. ACS Catal. 2022. PMID: 36339349 Free PMC article.

6

Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase-1.

Waheed SO, Varghese A, DiCastri I, Kaski B, LaRouche C, Fields GB, Karabencheva-Christova TG. Waheed SO, et al. Among authors: varghese a. Chemphyschem. 2023 Feb 1;24(3):e202200943. doi: 10.1002/cphc.202200943. Chemphyschem. 2023. PMID: 36723036 Free PMC article.

7

Catalytic Mechanism of Collagen Hydrolysis by Zinc(II)-Dependent Matrix Metalloproteinase-1.

Varghese A, Waheed SO, Gorantla K, DiCastri I, LaRouche C, Kaski B, Fields GB, Karabencheva-Christova TG. Varghese A, et al. J Phys Chem B. 2023 Nov 16;127(45):9697-9709. doi: 10.1021/acs.jpcb.3c04293. Epub 2023 Nov 6. J Phys Chem B. 2023. PMID: 37931179 Free PMC article.

8

Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH.

Krishnan A, Waheed SO, Varghese A, Cherilakkudy FH, Schofield CJ, Karabencheva-Christova TG. Krishnan A, et al. Among authors: varghese a. Chem Sci. 2024 Feb 5;15(10):3466-3484. doi: 10.1039/d3sc05974j. eCollection 2024 Mar 6. Chem Sci. 2024. PMID: 38455014 Free PMC article.

9

Revealing the Catalytic Strategy of FTO.

Varghese A, Waheed SO, Chaturvedi SS, DiCastri I, LaRouche C, Kaski B, Lehnert N, Li D, Christov CZ, Karabencheva-Christova TG. Varghese A, et al. Chem Catal. 2023 Sep 21;3(9):100732. doi: 10.1016/j.checat.2023.100732. Epub 2023 Aug 28. Chem Catal. 2023. PMID: 40636456 Free PMC article.

10

Catalytic Mechanism of the Bacterial Non-Heme Fe(II) and 2-Oxoglutarate Dependent Enzyme AlkB with Single-Stranded DNA Containing Complex Guanine Adducts.

Melayikandy S, Krishnan A, Varghese A, Jaber Sathik Rifayee SB, Waheed SO, Ramanan R, Li D, Christov CZ, Karabencheva-Christova TG. Melayikandy S, et al. Among authors: varghese a. Inorg Chem. 2025 Aug 4;64(30):15650-15666. doi: 10.1021/acs.inorgchem.5c02176. Epub 2025 Jul 24. Inorg Chem. 2025. PMID: 40706026 Free PMC article.

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