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Page 1
Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction.
Black JRM, Karasaki T, Abbott CW, Li B, Veeriah S, Al Bakir M, Liu WK, Huebner A, Martínez-Ruiz C, Pawlik P, Moore DA, Marinelli D, Shutkever O, Murphy C, Liu LY, Grieco C, Grimes K, Navarro FCP, Pyke RM, Bartha G, Keough KC, Dea S, Ravi N, Lyle J, Harris J, Brown KD, Blackhall FH, Hassani F, Fennell DA, McGranahan N, Shaw JA, Abbosh C; TRACERx Consortium; Hackshaw A, Jamal-Hanjani M, Frankell AM, Boyle SM, Chen RO, Swanton C. Black JRM, et al. Among authors: frankell am. Cell. 2025 Nov 7:S0092-8674(25)01192-4. doi: 10.1016/j.cell.2025.10.020. Online ahead of print. Cell. 2025. PMID: 41205598 Free article.
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
Gimeno-Valiente F, Castignani C, Larose Cadieux E, Mensah NE, Liu X, Chen K, Chervova O, Karasaki T, Weeden CE, Richard C, Lai S, Martínez-Ruiz C, Lim EL, Frankell AM, Watkins TBK, Stavrou G, Usaite I, Lu WT, Marinelli D, Saghafinia S, Wilson GA, Dhami P, Vaikkinen H, Steif J, Veeriah S, Hynds RE, Hirst M, Hiley C, Feber A, Deniz Ö, Jamal-Hanjani M, McGranahan N; TRACERx Consortium; Beck S, Demeulemeester J, Tanić M, Swanton C, Van Loo P, Kanu N. Gimeno-Valiente F, et al. Among authors: frankell am. Nat Genet. 2025 Sep;57(9):2226-2237. doi: 10.1038/s41588-025-02307-x. Epub 2025 Sep 10. Nat Genet. 2025. PMID: 40931149 Free PMC article.
Clone copy number diversity is linked to survival in lung cancer.
Pawlik P, Grigoriadis K, Bunkum A, Coggan H, Frankell AM, Martinez-Ruiz C, Karasaki T, Huebner A, Rowan A, Fisher J, Hackshaw A, Swanton C, Zaccaria S, McGranahan N. Pawlik P, et al. Among authors: frankell am. Nature. 2025 Oct;646(8083):190-197. doi: 10.1038/s41586-025-09398-w. Epub 2025 Aug 13. Nature. 2025. PMID: 40804524 Free PMC article.
Subclonal immune evasion in non-small cell lung cancer.
Dijkstra KK, Vendramin R, Karagianni D, Witsen M, Gálvez-Cancino F, Hill MS, Foster KA, Barbè V, Angelova M, Hynds RE, Pearce DR, Martínez-Ruiz C, Black JRM, Huebner A, Pich O, Rowan A, Augustine M, Puttick C, Moore DA, Liu LL, Saghafinia S, van de Haar J, Veeriah S, Naceur-Lombardelli C, Toncheva A, Bola SK, Hiley CT, Jamal-Hanjani M, McGranahan N, Litchfield K, Reading JL, Chain B; TRACERx consortium; Quezada SA, Voest EE, Swanton C. Dijkstra KK, et al. Cancer Cell. 2025 Oct 13;43(10):1833-1849.e10. doi: 10.1016/j.ccell.2025.06.012. Epub 2025 Jul 3. Cancer Cell. 2025. PMID: 40614739 Free article.
A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer.
Middleton G, Robbins HL, Fletcher P, Savage J, Mehmi M, Summers Y, Greystoke A, Steele N, Popat S, Jain P, Spicer J, Cave J, Shaw P, Gilligan D, Power D, Fennell D, Bajracharya M, McBride DJ, Maheswari U, Frankell AM, Swanton C, Beggs AD, Billingham L. Middleton G, et al. Among authors: frankell am. NPJ Precis Oncol. 2025 Mar 11;9(1):67. doi: 10.1038/s41698-025-00838-4. NPJ Precis Oncol. 2025. PMID: 40069402 Free PMC article.
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer.
Bentham R, Jones TP, Black JRM, Martinez-Ruiz C, Dietzen M, Litovchenko M, Thol K, Watkins TBK, Bailey C, Pich O, Zhang Z, Van Loo P; TRACERx Consortium; Genomics England Consortium; Swanton C, McGranahan N. Bentham R, et al. Nat Genet. 2025 Mar;57(3):694-705. doi: 10.1038/s41588-025-02086-5. Epub 2025 Feb 18. Nat Genet. 2025. PMID: 39966644 Free PMC article.
Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma.
Black JRM, Bartha G, Abbott CW, Boyle SM, Karasaki T, Li B, Chen R, Harris J, Veeriah S, Colopi M, Bakir MA, Liu WK, Lyle J, Navarro FCP, Northcott J, Pyke RM, Hill MS, Thol K, Huebner A, Bailey C, Colliver EC, Martínez-Ruiz C, Grigoriadis K, Pawlik P, Moore DA, Marinelli D, Shutkever OG, Murphy C, Sivakumar M; TRACERx consortium; Shaw JA, Hackshaw A, McGranahan N, Jamal-Hanjani M, Frankell AM, Chen RO, Swanton C. Black JRM, et al. Among authors: frankell am. Nat Med. 2025 Jan;31(1):70-76. doi: 10.1038/s41591-024-03216-y. Epub 2025 Jan 13. Nat Med. 2025. PMID: 39806071 Free PMC article.
Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma.
Biswas D, Liu YH, Herrero J, Wu Y, Moore DA, Karasaki T, Grigoriadis K, Lu WT, Veeriah S, Naceur-Lombardelli C, Magno N, Ward S, Frankell AM, Hill MS, Colliver E, de Carné Trécesson S, East P, Malhi A, Snell DM, O'Neill O, Leonce D, Mattsson J, Lindberg A, Micke P, Moldvay J, Megyesfalvi Z, Dome B, Fillinger J, Nicod J, Downward J, Szallasi Z; TRACERx Consortium; Hackshaw A, Jamal-Hanjani M, Kanu N, Birkbak NJ, Swanton C. Biswas D, et al. Among authors: frankell am. Nat Cancer. 2025 Jan;6(1):86-101. doi: 10.1038/s43018-024-00883-1. Epub 2025 Jan 9. Nat Cancer. 2025. PMID: 39789179 Free PMC article.
Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER.
Lucas O, Ward S, Zaidi R, Bunkum A, Frankell AM, Moore DA, Hill MS, Liu WK, Marinelli D, Lim EL, Hessey S, Naceur-Lombardelli C, Rowan A, Purewal-Mann SK, Zhai H, Dietzen M, Ding B, Royle G, Aparicio S; TRACERx Consortium; PEACE Consortium; McGranahan N, Jamal-Hanjani M, Kanu N, Swanton C, Zaccaria S. Lucas O, et al. Among authors: frankell am. Nat Genet. 2025 Jan;57(1):103-114. doi: 10.1038/s41588-024-01989-z. Epub 2024 Nov 29. Nat Genet. 2025. PMID: 39614124 Free PMC article.
MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution.
Puttick C, Jones TP, Leung MM, Galvez-Cancino F, Liu J, Varas-Godoy M, Rowan A, Pich O, Martinez-Ruiz C, Bentham R, Dijkstra KK, Black JRM, Rosenthal R, Kanu N, Litchfield K, Salgado R, Moore DA, Van Loo P, Jamal-Hanjani M, Quezada SA; TRACERx Consortium; Swanton C, McGranahan N. Puttick C, et al. Nat Genet. 2024 Oct;56(10):2121-2131. doi: 10.1038/s41588-024-01883-8. Epub 2024 Oct 2. Nat Genet. 2024. PMID: 39358601 Free PMC article.
29 results