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Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.
Song F, Kovac V, Mohammadi B, Littau JL, Scharfenberg F, Matamoros Angles A, Vanni I, Shafiq M, Orge L, Galliciotti G, Djakkani S, Linsenmeier L, Černilec M, Hartman K, Jung S, Tatzelt J, Neumann JE, Damme M, Tschirner SK, Lichtenthaler SF, Ricklefs FL, Sauvigny T, Schmitz M, Zerr I, Puig B, Tolosa E, Ferrer I, Magnus T, Rupnik MS, Sepulveda-Falla D, Matschke J, Šmid LM, Bresjanac M, Andreoletti O, Krasemann S, Foliaki ST, Nonno R, Becker-Pauly C, Monzo C, Crozet C, Haigh CL, Glatzel M, Curin Serbec V, Altmeppen HC. Song F, et al. Among authors: ferrer i. Acta Neuropathol. 2024 Jul 9;148(1):2. doi: 10.1007/s00401-024-02763-5. Acta Neuropathol. 2024. PMID: 38980441 Free PMC article.
Spontaneous generation of infectious prion disease in transgenic mice.
Torres JM, Castilla J, Pintado B, Gutiérrez-Adan A, Andréoletti O, Aguilar-Calvo P, Arroba AI, Parra-Arrondo B, Ferrer I, Manzanares J, Espinosa JC. Torres JM, et al. Among authors: ferrer i. Emerg Infect Dis. 2013 Dec;19(12):1938-47. doi: 10.3201/eid1912.130106. Emerg Infect Dis. 2013. PMID: 24274622 Free PMC article.
The repressor Capicua is a barrier to lung tumor development driven by Kras/Trp53 mutations.
Ballesteros-González I, Hernández-Navas I, Brehey O, Lechuga CG, Salmón M, Scotece M, Velasco-Vicente R, Flores-Gómez AA, Cebriá A, Simón-Carrasco L, Jiménez G, Musteanu M, Guerra C, Domínguez O, Caleiras E, Blanco-Aparicio C, Pons T, Ferrer I, Paz-Ares L, Torres-Ruiz R, Rodríguez-Perales S, Barbacid M, Drosten M. Ballesteros-González I, et al. Among authors: ferrer i. EMBO Mol Med. 2025 Nov 11. doi: 10.1038/s44321-025-00326-z. Online ahead of print. EMBO Mol Med. 2025. PMID: 41219537 Free article.
CDK7-targeted therapy effectively disrupts cell cycle progression and oncogenic signaling in head and neck cancer.
Otero-Rosales M, Álvarez-González M, Pazos I, de Luxán-Delgado B, Del Marro S, Pozo-Agundo E, Rodríguez-Santamaría M, López-Fernández A, Corte-Torres D, Granda-Díaz R, Álvarez-Teijeiro S, Fernández-Vega I, Lorz C, García-Escudero R, Rodrigo JP, Tzelepis K, Vassiliou G, Ferrer I, Álvarez-Fernández M, García-Pedrero JM, Hermida-Prado F. Otero-Rosales M, et al. Among authors: ferrer i. Signal Transduct Target Ther. 2025 Nov 6;10(1):363. doi: 10.1038/s41392-025-02452-z. Signal Transduct Target Ther. 2025. PMID: 41193441 Free PMC article.
1,372 results