Spring DR - Search Results

1

Novel immunotherapeutics against LGR5 to target multiple cancer types.

Chen HC, Mueller N, Stott K, Kapeni C, Rivers E, Sauer CM, Beke F, Walsh SJ, Ashman N, O'Brien L, Rafati Fard A, Ghodsinia A, Li C, Joud F, Giger O, Zlobec I, Olan I, Aitken SJ, Hoare M, Mair R, Serrao E, Brenton JD, Garcia-Gimenez A, Richardson SE, Huntly B, Spring DR, Skjoedt MO, Skjødt K, de la Roche M, de la Roche M. Chen HC, et al. Among authors: spring dr. EMBO Mol Med. 2024 Sep;16(9):2233-2261. doi: 10.1038/s44321-024-00121-2. Epub 2024 Aug 21. EMBO Mol Med. 2024. PMID: 39169164 Free PMC article.

2

Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence.

Wiedmann MM, Aibara S, Spring DR, Stewart M, Brenton JD. Wiedmann MM, et al. Among authors: spring dr. J Struct Biol. 2016 Sep;195(3):273-281. doi: 10.1016/j.jsb.2016.06.018. Epub 2016 Jun 21. J Struct Biol. 2016. PMID: 27346421 Free PMC article.

3

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.

Wiedmann MM, Tan YS, Wu Y, Aibara S, Xu W, Sore HF, Verma CS, Itzhaki L, Stewart M, Brenton JD, Spring DR. Wiedmann MM, et al. Among authors: spring dr. Angew Chem Int Ed Engl. 2017 Jan 9;56(2):524-529. doi: 10.1002/anie.201609427. Epub 2016 Dec 5. Angew Chem Int Ed Engl. 2017. PMID: 27918136 Free PMC article.

4

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.

Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvönen M, Verma C, Spring DR, Itzhaki LS. Xu W, et al. Among authors: spring dr. J Am Chem Soc. 2017 Feb 15;139(6):2245-2256. doi: 10.1021/jacs.6b10234. Epub 2017 Feb 7. J Am Chem Soc. 2017. PMID: 28084734 Free PMC article.

5

A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates.

Walsh SJ, Omarjee S, Galloway WRJD, Kwan TT, Sore HF, Parker JS, Hyvönen M, Carroll JS, Spring DR. Walsh SJ, et al. Among authors: spring dr. Chem Sci. 2018 Nov 9;10(3):694-700. doi: 10.1039/c8sc04645j. eCollection 2019 Jan 21. Chem Sci. 2018. PMID: 30774870 Free PMC article.

6

Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates.

Walsh SJ, Omarjee S, Galloway WRJD, Kwan TT, Sore HF, Parker JS, Hyvönen M, Carroll JS, Spring DR. Walsh SJ, et al. Among authors: spring dr. Chem Sci. 2018 Dec 13;10(2):633-634. doi: 10.1039/c8sc90248h. eCollection 2019 Jan 14. Chem Sci. 2018. PMID: 30778404 Free PMC article.

7

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.

Charoenpattarapreeda J, Tan YS, Iegre J, Walsh SJ, Fowler E, Eapen RS, Wu Y, Sore HF, Verma CS, Itzhaki L, Spring DR. Charoenpattarapreeda J, et al. Among authors: spring dr. Chem Commun (Camb). 2019 Jul 14;55(55):7914-7917. doi: 10.1039/c9cc04022f. Epub 2019 Jun 21. Chem Commun (Camb). 2019. PMID: 31225847

8

Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling.

Robertson NS , Walsh SJ , Fowler E , Yoshida M , Rowe SM , Wu Y , Sore HF , Parker JS , Spring DR . Robertson NS , et al. Among authors: spring dr. Chem Commun (Camb). 2019 Aug 7;55(64):9499-9502. doi: 10.1039/c9cc05042f. Chem Commun (Camb). 2019. PMID: 31328756

9

Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents.

Pettigrew TR, Porter RJ, Walsh SJ, Housden MP, Lam NYS, Carroll JS, Parker JS, Spring DR, Paterson I. Pettigrew TR, et al. Among authors: spring dr. Chem Commun (Camb). 2020 Feb 4;56(10):1529-1532. doi: 10.1039/c9cc09050a. Epub 2020 Jan 10. Chem Commun (Camb). 2020. PMID: 31922172

10

General dual functionalisation of biomacromolecules via a cysteine bridging strategy.

Walsh SJ, Iegre J, Seki H, Bargh JD, Sore HF, Parker JS, Carroll JS, Spring DR. Walsh SJ, et al. Among authors: spring dr. Org Biomol Chem. 2020 Jun 10;18(22):4224-4230. doi: 10.1039/d0ob00907e. Org Biomol Chem. 2020. PMID: 32432632

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