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Page 1
Proteo-metabolomics and patient tumor slice experiments point to amino acid centrality for rewired mitochondria in fibrolamellar carcinoma.
Long D Jr, Chan M, Han M, Kamdar Z, Ma RK, Tsai PY, Francisco AB, Barrow J, Shackelford DB, Yarchoan M, McBride MJ, Orre LM, Vacanti NM, Gujral TS, Sethupathy P. Long D Jr, et al. Among authors: shackelford db. Cell Rep Med. 2024 Sep 17;5(9):101699. doi: 10.1016/j.xcrm.2024.101699. Epub 2024 Aug 28. Cell Rep Med. 2024. PMID: 39208801 Free PMC article.
PGC-1α drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity.
Varuzhanyan G, Chen CC, Freeland J, He T, Tran W, Song K, Wang L, Cheng D, Xu S, Dibernardo GA, Esedebe FN, Bhatia V, Han M, Abt ER, Park JW, Memarzadeh S, Shackelford D, Lee JK, Graeber T, Shirihai O, Witte O. Varuzhanyan G, et al. bioRxiv [Preprint]. 2024 Jul 25:2024.04.09.588489. doi: 10.1101/2024.04.09.588489. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2416882121. doi: 10.1073/pnas.2416882121. PMID: 38645232 Free PMC article. Updated. Preprint.
Targeting FSP1 triggers ferroptosis in lung cancer.
Wu K, Vaughan AJ, Bossowski JP, Hao Y, Ziogou A, Kim SM, Kim TH, Nakamura MN, Pillai R, Mancini M, Rajalingam S, Han M, Nakamura T, Wang L, Chung S, Simeone D, Shackelford D, Kang YP, Conrad M, Papagiannakopoulos T. Wu K, et al. bioRxiv [Preprint]. 2025 Aug 23:2025.08.07.668766. doi: 10.1101/2025.08.07.668766. bioRxiv. 2025. Update in: Nature. 2025 Nov 5. doi: 10.1038/s41586-025-09710-8. PMID: 40832353 Free PMC article. Updated. Preprint.
OGDHL regulates tumor growth, neuroendocrine marker expression, and nucleotide abundance in prostate cancer.
Bernard MJ, Ruiz A, Diaz JA, Nunley NM, Dove RN, Zhang S, Lee E, Heering KY, Bopardikar S, Gallardo A, Hashimoto T, Agrawal R, Smith CM, Wilde BR, Matulionis N, Richards HM, Lee SCS, Sharifi MN, Lang JM, Zhao SG, Haffner MC, Shackelford DB, Boutros PC, Christofk HR, Goldstein AS. Bernard MJ, et al. Among authors: shackelford db. bioRxiv [Preprint]. 2025 Aug 22:2025.05.28.656673. doi: 10.1101/2025.05.28.656673. bioRxiv. 2025. PMID: 40502162 Free PMC article. Preprint.
PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity.
Varuzhanyan G, Chen CC, Freeland J, He T, Tran W, Song K, Wang L, Cheng D, Xu S, Dibernardo GA, Esedebe FN, Bhatia V, Han M, Abt ER, Park JW, Memarzadeh S, Shackelford DB, Lee JK, Graeber TG, Shirihai OS, Witte ON. Varuzhanyan G, et al. Among authors: shackelford db. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2416882121. doi: 10.1073/pnas.2416882121. Epub 2024 Nov 26. Proc Natl Acad Sci U S A. 2024. PMID: 39589879 Free PMC article.
Targeting Asparagine Metabolism in Well-Differentiated/Dedifferentiated Liposarcoma.
Klingbeil KD, Wilde BR, Graham DS, Lofftus S, McCaw T, Matulionis N, Dry SM, Crompton JG, Eilber FC, Graeber TG, Shackelford DB, Christofk HR, Kadera BE. Klingbeil KD, et al. Among authors: shackelford db. Cancers (Basel). 2024 Aug 30;16(17):3031. doi: 10.3390/cancers16173031. Cancers (Basel). 2024. PMID: 39272889 Free PMC article.
Trafficking of mitochondrial double-stranded RNA from mitochondria to the cytosol.
Krieger MR, Abrahamian M, He KL, Atamdede S, Hakimjavadi H, Momcilovic M, Ostrow D, Maggo SD, Tsang YP, Gai X, Chanfreau GF, Shackelford DB, Teitell MA, Koehler CM. Krieger MR, et al. Among authors: shackelford db. Life Sci Alliance. 2024 Jul 2;7(9):e202302396. doi: 10.26508/lsa.202302396. Print 2024 Sep. Life Sci Alliance. 2024. PMID: 38955468 Free PMC article.
N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma.
Geroyska S, Mejia I, Chan AA, Navarrete M, Pandey V, Kharpatin S, Noguti J, Wang F, Srole D, Chou TF, Wohlschlegel J, Nemeth E, Damoiseaux R, Shackelford DB, Lee DJ, Díaz B. Geroyska S, et al. Among authors: shackelford db. Cancer Res Commun. 2024 Jul 1;4(7):1815-1833. doi: 10.1158/2767-9764.CRC-23-0428. Cancer Res Commun. 2024. PMID: 38949950 Free PMC article.
51 results