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Therapygenetics: Serotonin transporter gene polymorphism (5-HTTLPR) is associated with behavioral treatment response to virtual exposure therapy in patients with spider phobia.
Schrammen E, Hilbrich C, Böhnlein J, Roesmann K, Gathmann B, Herrmann MJ, Junghöfer M, Schwarzmeier H, Seeger FR, Siminski N, Straube T, Weber H, Lueken U, Dannlowski U, Domschke K, Schiele MA, Leehr EJ. Schrammen E, et al. Among authors: siminski n. Eur Neuropsychopharmacol. 2025 Sep;98:46-48. doi: 10.1016/j.euroneuro.2025.07.002. Epub 2025 Jul 15. Eur Neuropsychopharmacol. 2025. PMID: 40669138
Functional near-infrared spectroscopy and vagus somatosensory evoked potentials add to the power of established parameters such as poor cognitive performance, dsyosmia and APOe genotype to predict cognitive decline over 8 years in the elderly.
Herrmann MJ, Wuttke A, Breuninger L, Eff J, Ettlinger S, Fischer M, Götzelmann A, Gram A, Pomper LD, Schneider E, Schwitalla L, Siminski N, Spielmann F, Weinmann E, Weyel V, Zeller JBM, Lauer M, Deckert J, Polak T. Herrmann MJ, et al. Among authors: siminski n. J Neural Transm (Vienna). 2025 Mar;132(3):455-468. doi: 10.1007/s00702-024-02859-y. Epub 2024 Nov 13. J Neural Transm (Vienna). 2025. PMID: 39535568 Free PMC article.
Resting-state functional connectivity in anxiety disorders: a multicenter fMRI study.
Langhammer T, Hilbert K, Adolph D, Arolt V, Bischoff S, Böhnlein J, Cwik JC, Dannlowski U, Deckert J, Domschke K, Evens R, Fydrich T, Gathmann B, Hamm AO, Heinig I, Herrmann MJ, Hollandt M, Junghoefer M, Kircher T, Koelkebeck K, Leehr EJ, Lotze M, Margraf J, Mumm JLM, Pittig A, Plag J, Richter J, Roesmann K, Ridderbusch IC, Schneider S, Schwarzmeier H, Seeger F, Siminski N, Straube T, Ströhle A, Szeska C, Wittchen HU, Wroblewski A, Yang Y, Straube B, Lueken U. Langhammer T, et al. Among authors: siminski n. Mol Psychiatry. 2025 Apr;30(4):1548-1557. doi: 10.1038/s41380-024-02768-2. Epub 2024 Oct 4. Mol Psychiatry. 2025. PMID: 39367057 Free PMC article.
Impact of NPSR1 gene variation on the neural correlates of phasic and sustained fear in spider phobia-an imaging genetics and independent replication approach.
Leehr EJ, Brede LS, Böhnlein J, Roesmann K, Gathmann B, Herrmann MJ, Junghöfer M, Schwarzmeier H, Seeger FR, Siminski N, Straube T, Klahn AL, Weber H, Schiele MA, Domschke K, Lueken U, Dannlowski U. Leehr EJ, et al. Among authors: siminski n. Soc Cogn Affect Neurosci. 2024 Sep 19;19(1):nsae054. doi: 10.1093/scan/nsae054. Soc Cogn Affect Neurosci. 2024. PMID: 39167471 Free PMC article.
Lack of evidence for predictive utility from resting state fMRI data for individual exposure-based cognitive behavioral therapy outcomes: A machine learning study in two large multi-site samples in anxiety disorders.
Hilbert K, Böhnlein J, Meinke C, Chavanne AV, Langhammer T, Stumpe L, Winter N, Leenings R, Adolph D, Arolt V, Bischoff S, Cwik JC, Deckert J, Domschke K, Fydrich T, Gathmann B, Hamm AO, Heinig I, Herrmann MJ, Hollandt M, Hoyer J, Junghöfer M, Kircher T, Koelkebeck K, Lotze M, Margraf J, Mumm JLM, Neudeck P, Pauli P, Pittig A, Plag J, Richter J, Ridderbusch IC, Rief W, Schneider S, Schwarzmeier H, Seeger FR, Siminski N, Straube B, Straube T, Ströhle A, Wittchen HU, Wroblewski A, Yang Y, Roesmann K, Leehr EJ, Dannlowski U, Lueken U. Hilbert K, et al. Among authors: siminski n. Neuroimage. 2024 Jul 15;295:120639. doi: 10.1016/j.neuroimage.2024.120639. Epub 2024 May 25. Neuroimage. 2024. PMID: 38796977 Free article.
Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia-a replication approach.
Leehr EJ, Seeger FR, Böhnlein J, Gathmann B, Straube T, Roesmann K, Junghöfer M, Schwarzmeier H, Siminski N, Herrmann MJ, Langhammer T, Goltermann J, Grotegerd D, Meinert S, Winter NR, Dannlowski U, Lueken U. Leehr EJ, et al. Among authors: siminski n. Transl Psychiatry. 2024 Mar 7;14(1):137. doi: 10.1038/s41398-024-02799-x. Transl Psychiatry. 2024. PMID: 38453896 Free PMC article.
Mechanisms of action underlying virtual reality exposure treatment in spider phobia: Pivotal role of within-session fear reduction.
Roesmann K, Leehr EJ, Böhnlein J, Gathmann B, Herrmann MJ, Junghöfer M, Schwarzmeier H, Seeger FR, Siminski N, Straube T, Dannlowski U, Lueken U. Roesmann K, et al. Among authors: siminski n. J Anxiety Disord. 2023 Dec;100:102790. doi: 10.1016/j.janxdis.2023.102790. Epub 2023 Oct 14. J Anxiety Disord. 2023. PMID: 37879242 Clinical Trial.
Individual-Level Prediction of Exposure Therapy Outcome Using Structural and Functional MRI Data in Spider Phobia: A Machine-Learning Study.
Chavanne AV, Meinke C, Langhammer T, Roesmann K, Boehnlein J, Gathmann B, Herrmann MJ, Junghoefer M, Klahn L, Schwarzmeier H, Seeger FR, Siminski N, Straube T, Dannlowski U, Lueken U, Leehr EJ, Hilbert K. Chavanne AV, et al. Among authors: siminski n. Depress Anxiety. 2023 Aug 22;2023:8594273. doi: 10.1155/2023/8594273. eCollection 2023. Depress Anxiety. 2023. PMID: 40224607 Free PMC article.
Neural correlates of fear conditioning are associated with treatment-outcomes to behavioral exposure in spider phobia - Evidence from magnetoencephalography.
Roesmann K, Toelle J, Leehr EJ, Wessing I, Böhnlein J, Seeger F, Schwarzmeier H, Siminski N, Herrmann MJ, Dannlowski U, Lueken U, Klucken T, Straube T, Junghöfer M. Roesmann K, et al. Among authors: siminski n. Neuroimage Clin. 2022;35:103046. doi: 10.1016/j.nicl.2022.103046. Epub 2022 May 13. Neuroimage Clin. 2022. PMID: 35609411 Free PMC article.
Centromedial amygdala is more relevant for phobic confrontation relative to the bed nucleus of stria terminalis in patients with spider phobia.
Siminski N, Borgmann L, Becker MPI, Hofmann D, Gathmann B, Leehr EJ, Böhnlein J, Seeger FR, Schwarzmeier H, Roesmann K, Junghöfer M, Dannlowski U, Lueken U, Straube T, Herrmann MJ. Siminski N, et al. J Psychiatr Res. 2021 Nov;143:268-275. doi: 10.1016/j.jpsychires.2021.09.003. Epub 2021 Sep 3. J Psychiatr Res. 2021. PMID: 34530337 Review.
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