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Muscle inflammation is regulated by NF-κB from multiple cells to control distinct states of wasting in cancer cachexia.
Pryce BR, Oles A, Talbert EE, Romeo MJ, Vaena S, Sharma S, Spadafora V, Tolliver L, Mahvi DA, Morgan KA, Lancaster WP, Beal E, Koren N, Watts B, Overstreet M, Berto S, Subramanian S, Calisir K, Crawford A, Neelon B, Ostrowski MC, Zimmers TA, Tidball JG, Wang DJ, Guttridge DC. Pryce BR, et al. Among authors: spadafora v. Cell Rep. 2024 Nov 26;43(11):114925. doi: 10.1016/j.celrep.2024.114925. Epub 2024 Oct 30. Cell Rep. 2024. PMID: 39475511 Free PMC article.
KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment.
Burge RA, Le Roux O, Popow O, Spadafora VK, Rajesh C, Adair SJ, Bialousow L, Murphy C, Saberi S, Vaena SG, Taquey MC, Allen S, Han L, Helke KL, Sharma S, Ostrowski MC, Guttridge DC, Dincman TA, Bauer TW, Kashatus DF, McFall T, Haigis KM, Hollingsworth MA, Counter CM, Der CJ, Hobbs GA. Burge RA, et al. Among authors: spadafora vk. Cancer Res. 2026 Jan 20. doi: 10.1158/0008-5472.CAN-25-2630. Online ahead of print. Cancer Res. 2026. PMID: 41556816