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Page 1
Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome.
Matico R, Grauwen K, Chauhan D, Yu X, Abdiaj I, Adhikary S, Adriaensen I, Aranzazu GM, Alcázar J, Bassi M, Brisse E, Cañellas S, Chaudhuri S, Delgado F, Diéguez-Vázquez A, Du Jardin M, Eastham V, Finley M, Jacobs T, Keustermans K, Kuhn R, Llaveria J, Leenaerts J, Linares ML, Martín ML, Martín-Pérez R, Martínez C, Miller R, Muñoz FM, Muratore ME, Nooyens A, Perez-Benito L, Perrier M, Pietrak B, Serré J, Sharma S, Somers M, Suarez J, Tresadern G, Trabanco AA, Van den Bulck D, Van Gool M, Van Hauwermeiren F, Varghese T, Vega JA, Youssef SA, Edwards MJ, Oehlrich D, Van Opdenbosch N. Matico R, et al. Among authors: grauwen k. EMBO Mol Med. 2025 Jan;17(1):54-84. doi: 10.1038/s44321-024-00181-4. Epub 2024 Dec 9. EMBO Mol Med. 2025. PMID: 39653810 Free PMC article.
NLRP3 inflammasome activation and pyroptosis are dispensable for tau pathology.
Paesmans I, Van Kolen K, Vandermeeren M, Shih PY, Wuyts D, Boone F, Garcia Sanchez S, Grauwen K, Van Hauwermeiren F, Van Opdenbosch N, Lamkanfi M, van Loo G, Bottelbergs A. Paesmans I, et al. Among authors: grauwen k. Front Aging Neurosci. 2024 Sep 24;16:1459134. doi: 10.3389/fnagi.2024.1459134. eCollection 2024. Front Aging Neurosci. 2024. PMID: 39381137 Free PMC article.
Structural basis for the oligomerization-facilitated NLRP3 activation.
Yu X, Matico RE, Miller R, Chauhan D, Van Schoubroeck B, Grauwen K, Suarez J, Pietrak B, Haloi N, Yin Y, Tresadern GJ, Perez-Benito L, Lindahl E, Bottelbergs A, Oehlrich D, Van Opdenbosch N, Sharma S. Yu X, et al. Among authors: grauwen k. Nat Commun. 2024 Feb 7;15(1):1164. doi: 10.1038/s41467-024-45396-8. Nat Commun. 2024. PMID: 38326375 Free PMC article.
IP-LC-MSMS Enables Identification of Three Tau O-GlcNAcylation Sites as O-GlcNAcase Inhibition Pharmacodynamic Readout in Transgenic Mice Overexpressing Human Tau.
Bijttebier S, Rodrigues Martins D, Mertens L, Grauwen K, Bruinzeel W, Willems R, Bartolomé-Nebreda JM, Theunis C, Bretteville A, Ebneth A, Dillen L. Bijttebier S, et al. Among authors: grauwen k. J Proteome Res. 2023 Apr 7;22(4):1309-1321. doi: 10.1021/acs.jproteome.2c00822. Epub 2023 Mar 8. J Proteome Res. 2023. PMID: 36888912
Development of immunoprecipitation - two-dimensional liquid chromatography - mass spectrometry methodology as biomarker read-out to quantify phosphorylated tau in cerebrospinal fluid from Alzheimer disease patients.
Bijttebier S, Theunis C, Jahouh F, Martins DR, Verhemeldonck M, Grauwen K, Dillen L, Mercken M. Bijttebier S, et al. Among authors: grauwen k. J Chromatogr A. 2021 Aug 16;1651:462299. doi: 10.1016/j.chroma.2021.462299. Epub 2021 May 28. J Chromatogr A. 2021. PMID: 34107398 Free article.
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón-Sandoval J, Ribe E, Winchester L, Webber C, Nevado A, Jacobs T, Austin N, Theunis C, Grauwen K, Daniela Ruiz E, Mudher A, Vicente-Rodriguez M, Parker CA, Simmons C, Cash D, Richardson J; NIMA Consortium; Jones DNC, Lovestone S, Gómez-Nicola D, Perry VH. Mancuso R, et al. Among authors: grauwen k. Brain. 2019 Oct 1;142(10):3243-3264. doi: 10.1093/brain/awz241. Brain. 2019. PMID: 31504240 Free PMC article.