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Pharmacological CLK inhibition disrupts SR protein function and RNA splicing blocking cell growth and migration in TNBC.
Breast Cancer Res. 2025 Jul 29;27(1):140. doi: 10.1186/s13058-025-02091-w.
Breast Cancer Res. 2025.
PMID: 40731028
Free PMC article.
LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype.
Cobo-Vuilleumier N, Rodríguez-Fernandez S, López-Noriega L, Lorenzo PI, Franco JM, Lachaud CC, Vazquez EM, Legido RA, Dorronsoro A, López-Férnandez-Sobrino R, Fernández-Santos B, Serrano CE, Salas-Lloret D, van Overbeek N, Ramos-Rodriguez M, Mateo-Rodríguez C, Hidalgo L, Marin-Canas S, Nano R, Arroba AI, Caro AC, Vertegaal AC, Martin-Montalvo A, Martín F, Aguilar-Diosdado M, Piemonti L, Pasquali L, Prieto RG, Sánchez MIG, Eizirik DL, Martínez-Brocca MA, Vives-Pi M, Gauthier BR.
Cobo-Vuilleumier N, et al. Among authors: van overbeek n.
Clin Transl Med. 2024 Dec;14(12):e70134. doi: 10.1002/ctm2.70134.
Clin Transl Med. 2024.
PMID: 39702941
Free PMC article.
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Deciphering non-canonical ubiquitin signaling: biology and methodology.
van Overbeek NK, Aguirre T, van der Heden van Noort GJ, Blagoev B, Vertegaal ACO.
van Overbeek NK, et al.
Front Mol Biosci. 2024 Feb 13;10:1332872. doi: 10.3389/fmolb.2023.1332872. eCollection 2023.
Front Mol Biosci. 2024.
PMID: 38414868
Free PMC article.
Review.
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Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates.
Trulsson F, Akimov V, Robu M, van Overbeek N, Berrocal DAP, Shah RG, Cox J, Shah GM, Blagoev B, Vertegaal ACO.
Trulsson F, et al. Among authors: van overbeek n.
Nat Commun. 2022 May 18;13(1):2736. doi: 10.1038/s41467-022-30376-7.
Nat Commun. 2022.
PMID: 35585066
Free PMC article.
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