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Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations.
Funk JS, Klimovich M, Drangenstein D, Pielhoop O, Hunold P, Borowek A, Noeparast M, Pavlakis E, Neumann M, Balourdas DI, Kochhan K, Merle N, Bullwinkel I, Wanzel M, Elmshäuser S, Teply-Szymanski J, Nist A, Procida T, Bartkuhn M, Humpert K, Mernberger M, Savai R, Soussi T, Joerger AC, Stiewe T. Funk JS, et al. Nat Genet. 2025 Jan;57(1):140-153. doi: 10.1038/s41588-024-02039-4. Epub 2025 Jan 7. Nat Genet. 2025. PMID: 39774325 Free PMC article.
DARPin-induced reactivation of p53 in HPV-positive cells.
Münick P, Strubel A, Balourdas DI, Funk JS, Mernberger M, Osterburg C, Dreier B, Schaefer JV, Tuppi M, Yüksel B, Schäfer B, Knapp S, Plückthun A, Stiewe T, Joerger AC, Dötsch V. Münick P, et al. Among authors: funk js. Nat Struct Mol Biol. 2025 May;32(5):790-801. doi: 10.1038/s41594-024-01456-7. Epub 2025 Jan 9. Nat Struct Mol Biol. 2025. PMID: 39789211
Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis.
Lenz J, Liefke R, Funk J, Shoup S, Nist A, Stiewe T, Schulz R, Tokusumi Y, Albert L, Raifer H, Förstemann K, Vázquez O, Tokusumi T, Fossett N, Brehm A. Lenz J, et al. PLoS Genet. 2021 Feb 18;17(2):e1009318. doi: 10.1371/journal.pgen.1009318. eCollection 2021 Feb. PLoS Genet. 2021. PMID: 33600407 Free PMC article.