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The XCL1-XCR1 axis supports intestinal tissue residency and antitumor immunity.
Ferry A, Mempel KM, Monell A, Reina-Campos M, Scharping NE, Heeg M, Takehara KK, Schokrpur S, Kuo N, Saddawi-Konefka R, Gutkind JS, Goldrath AW. Ferry A, et al. Among authors: gutkind js. J Exp Med. 2025 Mar 3;222(2):e20240776. doi: 10.1084/jem.20240776. Epub 2025 Jan 22. J Exp Med. 2025. PMID: 39841133
Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.
Paradis JS, Acosta M, Saddawi-Konefka R, Kishore A, Gomes F, Arang N, Tiago M, Coma S, Lubrano S, Wu X, Ford K, Day CP, Merlino G, Mali P, Pachter JA, Sato T, Aplin AE, Gutkind JS. Paradis JS, et al. Among authors: gutkind js. Clin Cancer Res. 2021 Jun 1;27(11):3190-3200. doi: 10.1158/1078-0432.CCR-20-3363. Epub 2021 Feb 10. Clin Cancer Res. 2021. PMID: 33568347 Free PMC article.
Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer.
Wang Z, Goto Y, Allevato MM, Wu VH, Saddawi-Konefka R, Gilardi M, Alvarado D, Yung BS, O'Farrell A, Molinolo AA, Duvvuri U, Grandis JR, Califano JA, Cohen EEW, Gutkind JS. Wang Z, et al. Among authors: gutkind js. Nat Commun. 2021 Apr 22;12(1):2383. doi: 10.1038/s41467-021-22619-w. Nat Commun. 2021. PMID: 33888713 Free PMC article.
Microneedle-mediated Intratumoral Delivery of Anti-CTLA-4 Promotes cDC1-dependent Eradication of Oral Squamous Cell Carcinoma with Limited irAEs.
Gilardi M, Saddawi-Konefka R, Wu VH, Lopez-Ramirez MA, Wang Z, Soto F, Ramms DJ, Proietto M, Mikulski Z, Miki H, Sharabi A, Kupor D, Rueda R, Hollern DP, Wang J, Gutkind JS. Gilardi M, et al. Among authors: gutkind js. Mol Cancer Ther. 2022 Apr 1;21(4):616-624. doi: 10.1158/1535-7163.MCT-21-0234. Mol Cancer Ther. 2022. PMID: 35086958 Free PMC article.
Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC.
Saddawi-Konefka R, O'Farrell A, Faraji F, Clubb L, Allevato MM, Jensen SM, Yung BS, Wang Z, Wu VH, Anang NA, Msari RA, Schokrpur S, Pietryga IF, Molinolo AA, Mesirov JP, Simon AB, Fox BA, Bui JD, Sharabi A, Cohen EEW, Califano JA, Gutkind JS. Saddawi-Konefka R, et al. Among authors: gutkind js. Nat Commun. 2022 Jul 25;13(1):4298. doi: 10.1038/s41467-022-31941-w. Nat Commun. 2022. PMID: 35879302 Free PMC article.
HER2 and HER3 as Therapeutic Targets in Head and Neck Cancer.
Saddawi-Konefka R, Schokrpur S, Lui AJ, Gutkind JS. Saddawi-Konefka R, et al. Among authors: gutkind js. Cancer J. 2022 Sep-Oct 01;28(5):339-345. doi: 10.1097/PPO.0000000000000622. Cancer J. 2022. PMID: 36165721 Free PMC article. Review.
The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure.
Wu VH, Yung BS, Faraji F, Saddawi-Konefka R, Wang Z, Wenzel AT, Song MJ, Pagadala MS, Clubb LM, Chiou J, Sinha S, Matic M, Raimondi F, Hoang TS, Berdeaux R, Vignali DAA, Iglesias-Bartolome R, Carter H, Ruppin E, Mesirov JP, Gutkind JS. Wu VH, et al. Among authors: gutkind js. Nat Immunol. 2023 Aug;24(8):1318-1330. doi: 10.1038/s41590-023-01529-7. Epub 2023 Jun 12. Nat Immunol. 2023. PMID: 37308665 Free PMC article.
Arrestins as rheostats of GPCR signalling.
Gutkind JS, Kostenis E. Gutkind JS, et al. Nat Rev Mol Cell Biol. 2018 Oct;19(10):615-616. doi: 10.1038/s41580-018-0041-y. Nat Rev Mol Cell Biol. 2018. PMID: 30026541 No abstract available.
Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential.
Dongre H, Rana N, Fromreide S, Rajthala S, Bøe Engelsen I, Paradis J, Gutkind JS, Vintermyr OK, Johannessen AC, Bjørge L, Costea DE. Dongre H, et al. Among authors: gutkind js. Exp Cell Res. 2020 Jan 1;386(1):111684. doi: 10.1016/j.yexcr.2019.111684. Epub 2019 Oct 23. Exp Cell Res. 2020. PMID: 31654625 Free article.
567 results