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Host albumin redirects Candida albicans metabolism to engage an alternative pathogenicity pathway.
Hitzler SUJ, Fernández-Fernández C, Günther K, Dietschmann A, Hovhannisyan H, Möslinger A, Austermeier S, Cristóvão B, Vascelli G, Zelante T, Pekmezović M, Ramírez-Zavala B, Morschhäuser J, Werz O, Gabaldón T, Jordan PM, Vylkova S, Gresnigt MS. Hitzler SUJ, et al. Among authors: dietschmann a. Nat Commun. 2025 Jul 12;16(1):6447. doi: 10.1038/s41467-025-61701-5. Nat Commun. 2025. PMID: 40646002 Free PMC article.
Lactic acid in the vaginal milieu modulates the Candida-host interaction.
Rosati D, Valentine M, Bruno M, Pradhan A, Dietschmann A, Jaeger M, Leaves I, van de Veerdonk FL, Joosten LAB, Roy S, Stappers MHT, Gow NAR, Hube B, Brown AJP, Gresnigt MS, Netea MG. Rosati D, et al. Among authors: dietschmann a. Virulence. 2025 Dec;16(1):2451165. doi: 10.1080/21505594.2025.2451165. Epub 2025 Jan 22. Virulence. 2025. PMID: 39843417 Free PMC article.
Alpha1-antitrypsin impacts innate host-pathogen interactions with Candida albicans by stimulating fungal filamentation.
Jaeger M, Dietschmann A, Austermeier S, Dinçer S, Porschitz P, Vornholz L, Maas RJA, Sprenkeler EGG, Ruland J, Wirtz S, Azam T, Joosten LAB, Hube B, Netea MG, Dinarello CA, Gresnigt MS. Jaeger M, et al. Among authors: dietschmann a. Virulence. 2024 Dec;15(1):2333367. doi: 10.1080/21505594.2024.2333367. Epub 2024 Apr 10. Virulence. 2024. PMID: 38515333 Free PMC article.
Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis.
Valentine M, Rudolph P, Dietschmann A, Tsavou A, Mogavero S, Lee S, Priest EL, Zhurgenbayeva G, Jablonowski N, Timme S, Eggeling C, Allert S, Dolk E, Naglik JR, Figge MT, Gresnigt MS, Hube B. Valentine M, et al. Among authors: dietschmann a. mBio. 2024 Mar 13;15(3):e0340923. doi: 10.1128/mbio.03409-23. Epub 2024 Feb 13. mBio. 2024. PMID: 38349176 Free PMC article.
18 results