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Broad Target Screening Reveals Abundance of FKBP12-Based Molecular Glues in Focused Libraries.
J Med Chem. 2025 May 8;68(9):9525-9536. doi: 10.1021/acs.jmedchem.5c00220. Epub 2025 Apr 28.
J Med Chem. 2025.
PMID: 40336336
Nondegradative Synthetic Molecular Glues Enter the Clinic.
Repity ML, Deutscher RCE, Hausch F.
Repity ML, et al.
ChemMedChem. 2025 May 19;20(10):e202500048. doi: 10.1002/cmdc.202500048. Epub 2025 Apr 14.
ChemMedChem. 2025.
PMID: 40226972
Free PMC article.
Review.
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Discovery of fully synthetic FKBP12-mTOR molecular glues.
Deutscher RCE, Meyners C, Repity ML, Sugiarto WO, Kolos JM, Maciel EVS, Heymann T, Geiger TM, Knapp S, Lermyte F, Hausch F.
Deutscher RCE, et al. Among authors: repity ml.
Chem Sci. 2025 Jan 13;16(10):4256-4263. doi: 10.1039/d4sc06917j. eCollection 2025 Mar 5.
Chem Sci. 2025.
PMID: 39916884
Free PMC article.
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Structure-Based Design of Ultrapotent Tricyclic Ligands for FK506-Binding Proteins.
Krajczy P, Meyners C, Repity ML, Hausch F.
Krajczy P, et al. Among authors: repity ml.
Chemistry. 2024 Aug 12;30(45):e202401405. doi: 10.1002/chem.202401405. Epub 2024 Jul 25.
Chemistry. 2024.
PMID: 38837733
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