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Page 1
Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity.
Yamazoe S, Poudel Y, Sega E, Mukhopadhyay A, Ramakrishnan R, Ukairo O, Liu S, Akter R, Sadanala K, Que K, Cheng Q, Kotapati S, Deshpande M, Cox M, Chourey S, Gupta A, Kempson J, Pabbisetty K, Kaspady M, Bhattasali D, Yip S, Wu DR, Pookot D, Li Y, Kozhich A, Drexler D, Carl S, Deyanova E, Smith M, Chan H, West S, Diong SJ, Chang A, Florin L, Mathur A, Strop P, Zapf CW, Law D, Wilson N, Broz M, Chekler EP. Yamazoe S, et al. Among authors: chekler ep. J Med Chem. 2025 Jun 12;68(11):11322-11339. doi: 10.1021/acs.jmedchem.5c00264. Epub 2025 May 24. J Med Chem. 2025. PMID: 40411528 Free PMC article.
Antibody-Drug Conjugates of NLRP3 Agonists: How Overcoming Lysosomal Accumulation Necessitated Noncanonical Linker Attachments.
Riehl PS, Zhang MY, Dhar P, Wang Z, Pan J, Mansfield K, Johnson WL, Zhang Q, Li Y, D'Souza R, Zhang J, Olsen J, Deshpande M, Kotapati S, Hollingsworth SA, Verma I, Li YX, Su Y, Cheng Q, Yamazoe S, Micci L, Broz M, Janc J, Chekler EP, Lo JC. Riehl PS, et al. Among authors: chekler ep. J Med Chem. 2025 May 8;68(9):9799-9810. doi: 10.1021/acs.jmedchem.5c00596. Epub 2025 Apr 29. J Med Chem. 2025. PMID: 40300109
Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells.
Sega E, Kotapati S, Poudel YB, Cheng Q, Sadanala K, Schneider B, Chekler EP, Rao C, Gangwar S, Sproul T, Law D, Broz M, Strop P, Yamazoe S. Sega E, et al. Among authors: chekler ep. Bioconjug Chem. 2025 Mar 19;36(3):437-448. doi: 10.1021/acs.bioconjchem.4c00534. Epub 2025 Feb 13. Bioconjug Chem. 2025. PMID: 39948340 Free PMC article.
Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach.
Poudel YB, Lo JC, Norris DJ, Cox M, He L, Johnson WL, A M Subbaiah M, Mondal S, Thangavel S, Subramani L, Reddy M, Jain S, Weiss DR, Sivaprakasam P, Critton D, Mulligan D, Xie C, Dhar P, Li Y, Sega E, Yamazoe S, Gavai AV, Mathur A, Zapf CW, Chekler EP. Poudel YB, et al. Among authors: chekler ep. ACS Med Chem Lett. 2024 Dec 19;16(1):80-88. doi: 10.1021/acsmedchemlett.4c00463. eCollection 2025 Jan 9. ACS Med Chem Lett. 2024. PMID: 39811121