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Page 1
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST.
Sprenger HG, Mittenbühler MJ, Sun Y, Van Vranken JG, Schindler S, Jayaraj A, Khetarpal SA, Smythers AL, Vargas-Castillo A, Puszynska AM, Spinelli JB, Armani A, Kunchok T, Ryback B, Seo HS, Song K, Sebastian L, O'Young C, Braithwaite C, Dhe-Paganon S, Burger N, Mills EL, Gygi SP, Paulo JA, Arthanari H, Chouchani ET, Sabatini DM, Spiegelman BM. Sprenger HG, et al. Among authors: gygi sp. Cell Metab. 2025 Apr 1;37(4):857-869.e9. doi: 10.1016/j.cmet.2025.01.024. Epub 2025 Feb 17. Cell Metab. 2025. PMID: 39965563
Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability.
Shaw BF, Arthanari H, Narovlyansky M, Durazo A, Frueh DP, Pollastri MP, Lee A, Bilgicer B, Gygi SP, Wagner G, Whitesides GM. Shaw BF, et al. Among authors: gygi sp. J Am Chem Soc. 2010 Dec 15;132(49):17411-25. doi: 10.1021/ja9067035. Epub 2010 Nov 19. J Am Chem Soc. 2010. PMID: 21090618 Free PMC article.
Fat cells directly sense temperature to activate thermogenesis.
Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP, Spiegelman BM. Ye L, et al. Among authors: gygi sp. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12480-5. doi: 10.1073/pnas.1310261110. Epub 2013 Jul 1. Proc Natl Acad Sci U S A. 2013. PMID: 23818608 Free PMC article.
765 results