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Transcriptomic profiling of the airway epithelium in COPD links airway eosinophilia to type 2 inflammation and corticosteroid response.
Leung C, Park HY, Li X, Koelwyn GJ, Tuong J, Vahedi SM, Leitao Filho FS, Yang JS, Eddy RL, Milne S, Ryu MH, Takiguchi H, Akata K, Ra SW, Moon JY, Kim HK, Cho Y, Yamasaki K, van Eeden SF, Shaipanich T, Lam S, Leung JM, Sin DD. Leung C, et al. Among authors: yang js. Eur Respir J. 2025 May 6;65(5):2401875. doi: 10.1183/13993003.01875-2024. Print 2025 May. Eur Respir J. 2025. PMID: 39978857 Clinical Trial.
Decreased microbiome diversity in the HIV small airway epithelium.
Xu S, Tsai A, Sze MA, Vucic EA, Shaipanich T, Harris M, Guillemi S, Yang J, Sinha S, Nislow C, Montaner J, Lam W, Lam S, Sin DD, Paul Man SF, Leung JM. Xu S, et al. Respir Res. 2018 Jul 27;19(1):140. doi: 10.1186/s12931-018-0835-7. Respir Res. 2018. PMID: 30053882 Free PMC article.
DNA methylation is associated with airflow obstruction in patients living with HIV.
Hernandez Cordero AI, Yang CX, Obeidat M, Yang J, MacIsaac J, McEwen L, Lin D, Kobor M, Novak R, Hudson F, Klinker H, Dharan N, Man SP, Sin DD, Kunisaki K, Leung J; INSIGHT START Pulmonary and Genomic Substudy Groups. Hernandez Cordero AI, et al. Thorax. 2021 May;76(5):448-455. doi: 10.1136/thoraxjnl-2020-215866. Epub 2020 Dec 18. Thorax. 2021. PMID: 33443234 Free PMC article. Clinical Trial.
Macrophages with reduced expressions of classical M1 and M2 surface markers in human bronchoalveolar lavage fluid exhibit pro-inflammatory gene signatures.
Takiguchi H, Yang CX, Yang CWT, Sahin B, Whalen BA, Milne S, Akata K, Yamasaki K, Yang JSW, Cheung CY, Vander Werff R, McNagny KM, Leitao Filho FS, Shaipanich T, van Eeden SF, Obeidat M, Leung JM, Sin DD. Takiguchi H, et al. Sci Rep. 2021 Apr 15;11(1):8282. doi: 10.1038/s41598-021-87720-y. Sci Rep. 2021. PMID: 33859282 Free PMC article.
Effects of Inhaled Corticosteroid/Long-Acting β2-Agonist Combination on the Airway Microbiome of Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Clinical Trial (DISARM).
Leitao Filho FS, Takiguchi H, Akata K, Ra SW, Moon JY, Kim HK, Cho Y, Yamasaki K, Milne S, Yang J, Yang CWT, Li X, Nislow C, van Eeden SF, Shaipanich T, Lam S, Leung JM, Sin DD. Leitao Filho FS, et al. Am J Respir Crit Care Med. 2021 Nov 15;204(10):1143-1152. doi: 10.1164/rccm.202102-0289OC. Am J Respir Crit Care Med. 2021. PMID: 34464242 Clinical Trial.
Ambient Air Pollution and Dysanapsis: Associations with Lung Function and Chronic Obstructive Pulmonary Disease in the Canadian Cohort Obstructive Lung Disease Study.
Bourbeau J, Doiron D, Biswas S, Smith BM, Benedetti A, Brook JR, Aaron SD, Chapman KR, Hernandez P, Maltais F, Marciniuk DD, O'Donnell D, Sin DD, Walker B, Dsilva L, Nadeau G, Coats V, Compton C, Miller BE, Tan WC; CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network. Bourbeau J, et al. Am J Respir Crit Care Med. 2022 Jul 1;206(1):44-55. doi: 10.1164/rccm.202106-1439OC. Am J Respir Crit Care Med. 2022. PMID: 35380941 Free PMC article.
1,949 results